Effect of remote ischemic conditioning on myocardial perfusion in patients with suspected ischemic coronary artery disease
| Autor: | Michael Schmidt, Camilla Molich Hoff, Kirsten Bouchelouche, Kasper Pryds, Hans Erik Bøtker, Lars Poulsen Tolbod, Jørgen Frøkiær, Jing Li, Andrew N. Redington, Roni Nielsen |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
Myocardial Ischemia positron emission tomography/computed tomography Coronary Artery Disease 030204 cardiovascular system & hematology 030218 nuclear medicine & medical imaging Coronary artery disease 0302 clinical medicine Positron Emission Tomography Computed Tomography hemic and lymphatic diseases Medicine Prospective Studies GENE-EXPRESSION remote ischemic conditioning medicine.diagnostic_test microRNA-144 Myocardial Perfusion Imaging Middle Aged RESERVE Positron emission tomography Ischemic Preconditioning Myocardial Cardiology HEART Female Cardiology and Cardiovascular Medicine Rubidium Radioisotopes Perfusion myocardial perfusion medicine.drug medicine.medical_specialty Ischemia 03 medical and health sciences CARDIOPROTECTION Rb-82-PET/CT Internal medicine Humans Radiology Nuclear Medicine and imaging Aged BLOOD-FLOW business.industry Blood flow QUANTIFICATION medicine.disease Adenosine ischemic heart disease LIMB ISCHEMIA MicroRNAs Rate pressure product ischemic preconditioning Exercise Test Ischemic preconditioning business |
| Zdroj: | Pryds, K, Nielsen, R R, Hoff, C M, Tolbod, L P, Bouchelouche, K, Li, J, Schmidt, M R, Redington, A N, Frøkiær, J & Bøtker, H E 2018, ' Effect of remote ischemic conditioning on myocardial perfusion in patients with suspected ischemic coronary artery disease ', Journal of Nuclear Cardiology, vol. 25, no. 3, pp. 887-896 . https://doi.org/10.1007/s12350-016-0709-7 |
| DOI: | 10.1007/s12350-016-0709-7 |
| Popis: | Background. Remote ischemic conditioning (RIC) confers protection against myocardial ischemia-reperfusion injury and may modulate coronary blood flow. We investigated whether RIC affects resting myocardial perfusion (MP) in patients with suspected ischemic coronary artery disease by quantitative MP imaging.Methods and Results. We included 49 patients with suspected ischemic coronary artery disease. Resting MP was quantified by 82 Rubidium positron emission tomography/computed tomography (Rb-82-PET/CT) imaging before and after RIC, performed as four cycles of 5 minutes upper arm ischemia and reperfusion. Subsequent adenosine Rb-82-PET/CT stress-imaging identified non-ischemic and reversibly ischemic myocardial segments. MicroRNA-144 plasma levels were measured before and after RIC. Normalized for rate pressure product, RIC did not affect MP globally (P = .64) or in non-ischemic myocardial segmene in MPts (P = .58) but decreased MP in reversibly ischemic myocardial segments (-0.11 mL/min/g decreas following RIC; 95% CI -0.17 to -0.06, P Conclusions. RIC did not substantially affect resting MP globally or in non-ischemic and reversibly ischemic myocardial territories in patients with suspected ischemic coronary artery disease. |
| Databáze: | OpenAIRE |
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