The effect of downhill running on Notch signaling in regenerating skeletal muscle
| Autor: | Susan K. Tsivitse, Angel L. Stoy, Robert S. Bowen, Jeffrey A. Mundy, Michael G. Peters |
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| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Physiology Notch signaling pathway Hindlimb Desmin Running Lesion Mice Physical Conditioning Animal Physiology (medical) Internal medicine medicine Animals Regeneration Myocyte Orthopedics and Sports Medicine Muscle Skeletal Notch 1 Cells Cultured Receptors Notch Chemistry Public Health Environmental and Occupational Health Skeletal muscle General Medicine Anatomy Cadherins Mice Inbred C57BL Endocrinology medicine.anatomical_structure medicine.symptom Signal Transduction Muscle contraction |
| Zdroj: | European Journal of Applied Physiology. 106:759-767 |
| ISSN: | 1439-6327 1439-6319 |
| DOI: | 10.1007/s00421-009-1077-7 |
| Popis: | Notch signaling expression in regenerating muscle following injurious downhill running (DHR) was characterized in male C57BL/J6 mice (3 mo). Hindlimb muscles were harvested from control mice or at 24, 48, 72, 96 or 120 h post-DHR. Muscle injury was observed at 96 h (3.3-fold) and 120 h (3.7-fold) post-DHR (P < 0.01) and elevated MCadherin expression at 72 h (2.7-fold), 96 h (2.4-fold) post-DHR (P < 0.05) and 120 h (3.3-fold) post-DHR (P < 0.01). Desmin increased at 72 h (2.2-fold), 96 h (3-fold) and 120 h (1.8-fold) post-DHR (P < 0.05). Delta1 +/MCadherin + cells increased ~2-fold at 72, 96 (P < 0.01) and 120 h post-DHR (P < 0.05). Isolated muscle-associated cells increased Delta1 (2.6-fold) (P < 0.05) and Notch1 (fourfold) (P < 0.01) expression at 120 h post-DHR. The results of this novel study indicate that DHR up-regulates Notch components within myoblasts and regenerating muscle. |
| Databáze: | OpenAIRE |
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