Age-related differences in glucose abnormalities in women with ST-elevation myocardial infarction submitted to percutaneous coronary intervention
| Autor: | Maria Grazia D'Alfonso, Gian Franco Gensini, Chiara Lazzeri, Marco Chiostri, Serafina Valente, Paola Attanà |
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| Rok vydání: | 2015 |
| Předmět: |
Blood Glucose
medicine.medical_specialty medicine.medical_treatment Myocardial Infarction Logistic regression Percutaneous Coronary Intervention Internal medicine Humans Medicine Hospital Mortality Myocardial infarction Aged Aged 80 and over business.industry Proportional hazards model Hazard ratio Age Factors Percutaneous coronary intervention General Medicine Odds ratio Middle Aged Prognosis medicine.disease Confidence interval Intensive Care Units Hyperglycemia Conventional PCI Cardiology Female Insulin Resistance Cardiology and Cardiovascular Medicine business |
| Zdroj: | Journal of Cardiovascular Medicine. 16:321-325 |
| ISSN: | 1558-2027 |
| DOI: | 10.2459/jcm.0000000000000003 |
| Popis: | No datum is so far available on the relation between age and the acute glucose response to stress in women with ST-elevation myocardial infarction (STEMI) treated with percutaneous coronary intervention (PCI).We evaluated the age-related differences in the acute glucose response in 373 STEMI women submitted to PCI. The oldest women, when compared to the other age subgroups, showed the higher admission and peak glycemia (P < 0.001 and P < 0.001, respectively) in the lack of differences in insulin, C-peptide, hemoglobin-glycated values and discharge glycemia values. At logistic regression analysis, the following variables were independent predictors of in-Intensive Cardiac Care Unit mortality: age (1-year step) [odds ratio 1.09, 96% confidence interval (CI) 1.04-1.15, P = 0.001], admission glycemia (1g/l step) (odds ratio 2.05, 96% CI 1.35-3.12, P < 0.001). At Cox regression analysis the following variables were associated with 1-year mortality (when adjusted for discharge glycemia): age (1-year step) (hazard ratio 1.13, 95% CI 1.04-1.22, P = 0.005), estimated glomerular filtration rate (1 g/l step) (hazard ratio 0.93, 95% CI 0.90-0.96, P < 0.001).Age affects the acute glucose response to myocardial injury since older women showed the higher admission glucose values and the poorer in-hospital glucose control, in the lack of differences of insulin-resistance incidence. Glucose values were independent predictors of in-hospital mortality, but were not related to long-term survival. |
| Databáze: | OpenAIRE |
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