Essential Hypertension: A Metabolic Cause? A Hypothesis
| Autor: | Eduardo Macieira-Coelho, Antonio Reis-Valle, Mario Garcia-Alves |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
Adult
Male medicine.medical_specialty Captopril chemistry.chemical_element Blood Pressure Spironolactone Calcium Essential hypertension Potassium Chloride chemistry.chemical_compound Internal medicine Renin Renin–angiotensin system medicine Humans Lactic Acid Hyperaldosteronemia Aldosterone Aged business.industry Metabolic disorder Middle Aged medicine.disease Propranolol Hydrochlorothiazide Endocrinology Blood pressure chemistry Pathophysiology of hypertension Hypertension Lactates Potassium Female Cardiology and Cardiovascular Medicine business |
| Zdroj: | Angiology. 36:305-309 |
| ISSN: | 1940-1574 0003-3197 |
| DOI: | 10.1177/000331978503600507 |
| Popis: | Forty-five hypertensive patients, 28 women and 17 men, age range between 35 and 65 years (mean 50 years), with blood pressures which current therapy did not succeed to control, were submitted to several examinations in order to identify the cause of their hypertension. We found isolated or combinated ab normal values of aldosterone, renin, calcium and or potassium as the only alter ations in 19 patients. We distinguished 4 groups descretionarily classified according to biochemical alterations: renin and aldosterone increase, renin in crease, aldosterone increase, calcium and or potassium reduction. The therapy used, intentionally aimed at the correction of the biochemical alterations found. Normal blood pressure was achieved in all patients and si multaneously the biochemical alterations also became normal in patients with isolated hyperreninemia, with combined hyperreninemia and hyperaldos teronemia and in those with hypocalcemia and or hypopotassemia. In patients were only isolated hyperaldosteronemia was found, this condition returned to normal in all except one. We suggest that besides the disturbances in sodium distribution other elec trolytes or biochemical alterations may also play an equally important role in regulating, and sustaining essential hypertension. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|