Antitussive Activity of the Ethanolic Extract of Paederia foetida (Rubiaceae family) in Non-Anaesthetized Cats
| Autor: | Gabriela Nosáľová, J. Mokrý, M. T. H. Khan, A. Ather |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
antitussive activity
Oral dose lcsh:Veterinary medicine Rubiaceae CATS General Veterinary biology Traditional medicine dropropizine Chemistry Paederia foetida Codeine Paederia conscious cats Anaesthetized cats Pharmacology biology.organism_classification Dropropizine Cough Antitussive Agent medicine lcsh:SF600-1100 codeine medicine.drug |
| Zdroj: | Acta Veterinaria Brno, Vol 76, Iss 1, Pp 27-33 (2007) |
| ISSN: | 1801-7576 0001-7213 |
| DOI: | 10.2754/avb200776010027 |
| Popis: | The aim of the present study was to examine the antitussive activity of the ethanolic extract of Paederia foetida (P. foetida) in conscious cats by mechanical stimulation of laryngopharyngeal (LP) and tracheobronchial (TB) mucous areas of airways. The results showed that the ethanolic extract of P. foetida at the oral dose of 200 mg kg-1 b.w. had a cough-suppressive effect. It caused a significant (p < 0.05) decrease of the number of cough efforts (NE) and frequency of cough (NE.min-1) from both LP and TB areas. The intensity of a cough attack was significantly decreased only during inspirium (IA-). Also a significant (p < 0.05) decrease was observed of the intensity of maximal effort in expirium (IME+) from TB area and inspirium (IME-) from both LP and TB areas. The antitussive activity of the ethanolic extract of P. foetida was lower than that of the classical narcotic antitussive drug - codeine, but similar to that of the non-narcotic antitussive agent dropropizine. The antitussive activity of the ethanolic extract of P. foetida may be connected with its previously demonstrated anti-inflammatory activity. |
| Databáze: | OpenAIRE |
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