Circulating tumour DNA reflects treatment response and clonal evolution in chronic lymphocytic leukaemia
Autor: | Pasquale Petrone, Andjelija Zivanovic, Sarah Ftouni, Devbarna Sinha, Constantine S. Tam, Maria Joao Silva, Tane Hunter, Gisela Mir Arnau, Paul Yeh, Rishu Agarwal, Ken Doig, Kate Jones, Enid Y.N. Lam, Ravikiran Vedururu, John F. Seymour, Timothy Semple, Mark A. Dawson, Damian Jiang, Stephen Q. Wong, Piers Blombery, Meaghan Wall, Sarah-Jane Dawson, Yih-Chih Chan, Anthony T. Papenfuss, Elise Wallach, David Westerman |
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Jazyk: | angličtina |
Rok vydání: | 2017 |
Předmět: |
0301 basic medicine
Male General Physics and Astronomy Disease Ataxia Telangiectasia Mutated Proteins Somatic evolution in cancer Circulating Tumor DNA 0302 clinical medicine Piperidines immune system diseases hemic and lymphatic diseases Receptor Notch1 Aged 80 and over Sulfonamides Multidisciplinary Hematology Middle Aged Baculoviral IAP Repeat-Containing 3 Protein 3. Good health Leukemia medicine.anatomical_structure Treatment Outcome 030220 oncology & carcinogenesis Disease Progression Female RNA Splicing Factors medicine.medical_specialty Science Antineoplastic Agents Biology General Biochemistry Genetics and Molecular Biology Article Clonal Evolution Proto-Oncogene Proteins p21(ras) 03 medical and health sciences Internal medicine medicine Humans B cell Aged Adenine Cancer General Chemistry medicine.disease Bridged Bicyclo Compounds Heterocyclic Phosphoproteins Minimal residual disease Leukemia Lymphocytic Chronic B-Cell Lymphoma 030104 developmental biology Pyrimidines Immunology Myeloid Differentiation Factor 88 Pyrazoles Tumor Suppressor Protein p53 |
Zdroj: | Nature Communications, Vol 8, Iss 1, Pp 1-7 (2017) Nature Communications |
ISSN: | 2041-1723 |
Popis: | Several novel therapeutics are poised to change the natural history of chronic lymphocytic leukaemia (CLL) and the increasing use of these therapies has highlighted limitations of traditional disease monitoring methods. Here we demonstrate that circulating tumour DNA (ctDNA) is readily detectable in patients with CLL. Importantly, ctDNA does not simply mirror the genomic information contained within circulating malignant lymphocytes but instead parallels changes across different disease compartments following treatment with novel therapies. Serial ctDNA analysis allows clonal dynamics to be monitored over time and identifies the emergence of genomic changes associated with Richter's syndrome (RS). In addition to conventional disease monitoring, ctDNA provides a unique opportunity for non-invasive serial analysis of CLL for molecular disease monitoring. Disease monitoring of chronic lymphocytic leukaemia (CLL) is a challenge. Here, the authors show that serial ctDNA analysis in 32 CLL patients allows monitoring of clonal dynamics over time, and identifies the emergence of genomic changes associated with Richter's syndrome. |
Databáze: | OpenAIRE |
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