Combining radioisotopic and blue-dye technique does not improve the false-negative rate in sentinel lymph node mapping for colorectal cancer
| Autor: | Francis Dubois, Paul A. Lehur, Olivier Tiffet, Sherban Bageacu, David Kaczmarek, Eric Bourgeois, Nathalie Prevot, Thomas Guillan, Marie Laure Chambonnière, Sylviane Baccot, Elisabeth Cassagnau |
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| Rok vydání: | 2007 |
| Předmět: |
Male
medicine.medical_specialty Colorectal cancer Sentinel lymph node Colonoscopy Injections Intralesional Metastasis Predictive Value of Tests Submucosa Rosaniline Dyes Medicine Humans Prospective Studies Retroperitoneal Space Coloring Agents Radionuclide Imaging False Negative Reactions Aged Neoplasm Staging Aged 80 and over medicine.diagnostic_test business.industry Sentinel Lymph Node Biopsy Micrometastasis Gastroenterology General Medicine Sentinel node Middle Aged medicine.disease Surgery Lymphatic system medicine.anatomical_structure Colorimetry Female Lymph Nodes business Nuclear medicine Colorectal Neoplasms Follow-Up Studies |
| Zdroj: | Diseases of the colon and rectum. 50(7) |
| ISSN: | 0012-3706 |
| Popis: | This study was designed to assess the feasibility of a combined colorimetric and radioisotopic technique in the detection of the sentinel lymph node in colorectal cancer. This prospective dual-center study included 64 patients. Using endoscopy on D0, a radiolabeled colloid was injected into the peritumoral submucosa, followed by a lymphoscintigraphy. Intraoperatively, on D1, lymphatic mapping was performed by using a visual method and radioguided detection after subserosal peritumoral injection of patent blue. Twenty-nine patients were injected only with the patent blue, 18 patients only with the radioactive tracer, and the other 17 patients benefited from both techniques. The detection rate was 92 percent. The average number of sentinel nodes harvested was 2.8. Twenty-four of 59 patients were pN+ (40 percent) and in 12 cases the sentinel lymph node was histologically negative, although there was a positive nonsentinel node (false-negative rate, 50 percent). The false-negative rate for the combined, radioisotopic, and colorimetric techniques were 63, 60, and 36 percent, respectively. In four patients, the sentinel node was the only metastatic site (4/24, 17 percent), and in two of these four patients, the sentinel lymph node presented with micrometastases ( |
| Databáze: | OpenAIRE |
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