Mice lacking myeloperoxidase are more susceptible to experimental autoimmune encephalomyelitis
| Autor: | Amitabh Gaur, Aldons J. Lusis, Marie-Luise Brennan, Anil Pahuja, Wanda F. Reynolds |
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| Rok vydání: | 2001 |
| Předmět: |
Pathology
medicine.medical_specialty Encephalomyelitis Autoimmune Experimental animal diseases Immunology Nitric Oxide Synthase Type II Hindlimb medicine.disease_cause Autoimmunity Interferon-gamma Mice medicine Demyelinating disease Animals Immunology and Allergy Interferon gamma Peroxidase Mice Knockout biology Multiple sclerosis Experimental autoimmune encephalomyelitis medicine.disease Mice Inbred C57BL Neuroimmunology Neurology Myeloperoxidase biology.protein Disease Susceptibility Neurology (clinical) Nitric Oxide Synthase medicine.drug |
| Zdroj: | Journal of Neuroimmunology. 112:97-105 |
| ISSN: | 0165-5728 |
| Popis: | EAE is a demyelinating disease which serves as an animal model for multiple sclerosis (MS). Myeloperoxidase (MPO) has been implicated in MS through its presence in invading macrophages, and by association of a -463G/A promoter polymorphism with increased risk. Also, MPO at 17q23.1 is within a region identified in genome scans as a MS susceptibility locus. We here examine the incidence of EAE in MPO knockout (KO) mice. MPO is detected in invading macrophages in the CNS of wild-type mice, yet unexpectedly, MPO-KO mice have significantly increased incidence of EAE: Ninety percent of MPO-KO mice developed complete hind limb paralysis as compared to 33% of wildtype (WT) littermates (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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