Fluorodeoxyglucose positron emission tomography/computed tomography in the diagnosis, assessment of disease activity and therapeutic response in relapsing polychondritis
| Autor: | Aman Sharma, Apurva Sood, Gsrsnk Naidu, Rajender Kumar, Adarsh Mb, Bhagwant Rai Mittal, Harmandeep Singh, Varun Dhir, Vikas Sharma, Sanjay Jain, Roshan K. Verma, Anish Bhattacharya |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Laryngeal Cartilages Stridor Standardized uptake value Asymptomatic Young Adult 03 medical and health sciences 0302 clinical medicine Nasal Cartilages Rheumatology Fluorodeoxyglucose F18 Recurrence Reference Values Positron Emission Tomography Computed Tomography medicine Humans Pharmacology (medical) Clinical significance Polychondritis Relapsing Young adult Nose Relapsing polychondritis Respiratory Sounds 030203 arthritis & rheumatology business.industry Middle Aged medicine.disease medicine.anatomical_structure Cough 030220 oncology & carcinogenesis Female Radiology Radiopharmaceuticals medicine.symptom business Progressive disease Ear Auricle |
| Zdroj: | Rheumatology. 59:99-106 |
| ISSN: | 1462-0332 1462-0324 |
| Popis: | Objective To evaluate 18F-fluorodeoxyglucose (FDG) PET/CT in the assessment of disease activity, extent of the disease and response to therapy in relapsing polychondritis. Methods Twenty-five patients (9 men, 16 women) with a mean age of 38.2 years (s.d. 13.7; range 18–62), diagnosed to have relapsing polychondritis according to Damiani and Levine’s modification of McAdam’s criteria, who underwent PET/CT examination were included. Ten patients underwent a second PET/CT examination after therapy or during follow-up. Clinical symptoms and auxiliary examination findings were recorded. PET/CT findings were reviewed and correlated with the clinical symptoms. Results The major symptoms were aural pain (n = 21), nasal pain (n = 10), stridor (n = 5), cough (n = 9), fever (n = 8) and laryngeal tenderness (n = 8). The initial PET/CT was positive in 23/25 patients. PET/CT revealed involvement of auricular (n = 14), nasal (n = 8), laryngeal (n = 7), tracheobronchial (n = 6) and Eustachian (n = 3) cartilages with a mean maximum standardized uptake value (SUVmax) of 4.1 (s.d. 2.5; range 1.7–12.7). Fair correlation of aural/nasal pain/stridor with FDG avidity of cartilage involvement on PET/CT was noted. The key finding was detection of asymptomatic large airway involvement in seven patients (28%). Re-examination PET in 10 patients revealed complete therapeutic response (n = 5), partial response (n = 1), stable disease (n = 1), progressive disease (n = 1) and disease recurrence (n = 2). Conclusion FDG PET/CT is a useful tool for the assessment of the disease activity and extent. It identified activity in clinically inaccessible sites that are of clinical significance. It is also useful in assessing treatment response and finding relapse. |
| Databáze: | OpenAIRE |
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