Severe Prolonged Red Blood Cell Aplasia and Thrombocytopenia Induced by Parvovirus B19 Infection in a Patient with Sarcoidosis
| Autor: | Marie Parrens, Jean-Michel Boiron, Marie-Edith Lafon, Olivier Hermine, Gerald Marit, Josy Reiffers, Jean-Luc Pellegrin, Jean-François Viallard |
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| Rok vydání: | 2003 |
| Předmět: |
Adult
Microbiology (medical) Systemic disease Pathology medicine.medical_specialty Sarcoidosis Bone Marrow Aplasia Red-Cell Aplasia Pure Peripheral blood mononuclear cell Parvoviridae Infections Parvovirus Interferon-gamma hemic and lymphatic diseases medicine Humans Reticulocytopenia biology business.industry Aplasia medicine.disease biology.organism_classification Thrombocytopenia Red blood cell Infectious Diseases medicine.anatomical_structure Immunology Female business |
| Zdroj: | Clinical Infectious Diseases. 36:229-233 |
| ISSN: | 1537-6591 1058-4838 |
| Popis: | We describe an acromegalic patient who developed a parvovirus B19 (PVB19) infection concomitantly with sarcoidosis, which was complicated by chronic red blood cell aplasia and severe thrombocytopenia, despite disappearance of the virus from serum and the production of high levels of specific polyclonal antibodies to PVB19. Mitogen stimulation of the patient's peripheral blood mononuclear cells induced oversecretion of interferon-gamma (IFN-gamma). Because hematopoietic suppression by IFN-gamma has been reported, a possible mechanism underlying reticulocytopenia and thrombocytopenia could involve IFN-gamma. |
| Databáze: | OpenAIRE |
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