Baclofen toxicosis in dogs and cats: 145 cases (2004–2010)
| Autor: | Roxanna Khorzad, Megan F. Whelan, Lynn R. Hovda, Justine A. Lee, Lee T Miyahara, Elizabeth P. Martin, Ahna G. Brutlag |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Baclofen Poison Control Centers Cat Diseases chemistry.chemical_compound Dogs Animals Medicine Dog Diseases Animal poison Retrospective Studies CATS General Veterinary Muscle Relaxants Central business.industry Genitourinary system Retrospective cohort study body regions Patient population chemistry Anesthesia General malaise Cats Female Electronic database business |
| Zdroj: | Journal of the American Veterinary Medical Association. 241:1059-1064 |
| ISSN: | 0003-1488 |
| DOI: | 10.2460/javma.241.8.1059 |
| Popis: | Objective—To identify dogs and cats with baclofen toxicosis and characterize the patient population, clinical signs, and outcome. Design—Retrospective case series. Animals—140 dogs and 5 cats with baclofen toxicosis. Procedures—An animal poison control center electronic database was reviewed from November 2004 through April 2010 to identify dogs and cats with baclofen toxicosis. Information on signalment, clinical signs, and amount of baclofen ingested was obtained. Clinical signs were categorized as CNS, gastrointestinal, general malaise, cardiovascular, respiratory, or urogenital. Follow-up communications were performed to determine overall outcome. Results—Dogs had a median age of 0.67 years (range, 0.1 to 15 years) and cats of 1 year (range, 0.7 to 16 years). Of 145 patients, 133 (92%) developed clinical signs of baclofen toxicosis. A total of 259 signs fell within defined categories: CNS (121/259 [46.7%]), gastrointestinal (69/259 [26.6%]), general malaise (27/259 [10.4%]), cardiovascular (23/259 [8.9%]), respiratory (14/259 [5.4%]), and urogenital (5/259 [1.9%]). For 68 dogs with known survival status, survival rate was 83.8% (57/68); of these dogs, the amount of baclofen ingested was known for 53 (46 survivors and 7 nonsurvivors). Amount of baclofen ingested was significantly lower in survivor dogs (median, 4.2 mg/kg [1.91 mg/lb]; range, 0.61 to 61 mg/kg [0.28 to 27.7 mg/lb]), compared with nonsurvivor dogs (median, 14 mg/kg [6.4 mg/lb]; range, 2.3 to 52.3 mg/kg [1.04 to 23.77 mg/lb]. Of 5 cats, 2 survived, 1 died, and 2 had unknown outcomes. Conclusions and Clinical Relevance—Clinical signs of baclofen toxicosis occurred in most patients, with the CNS being the system most commonly affected. |
| Databáze: | OpenAIRE |
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