The pathologic relevance of metabolic criteria in patients with biopsy-proven nonalcoholic fatty liver disease and metabolic dysfunction associated fatty liver disease: A multicenter cross-sectional study in China
| Autor: | Yuqiang Mi, Junping Shi, Rui-Xu Yang, Jia Shang, Branko Popovic, Qin Du, Hong Deng, Fang-Ping He, Jian-Gao Fan, Fu-Sheng Di, Yong-Jian Zhou, Jinjun Chen, Caiyan Zhao, Rui-Dan Zheng, Zheng-Sheng Zou, Bi-Hui Zhong |
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| Rok vydání: | 2021 |
| Předmět: |
Liver Cirrhosis
China medicine.medical_specialty Cirrhosis Biopsy Gastroenterology Insulin resistance Non-alcoholic Fatty Liver Disease Internal medicine Diabetes mellitus Nonalcoholic fatty liver disease medicine Humans Metabolic Syndrome Hepatology medicine.diagnostic_test business.industry Fatty liver nutritional and metabolic diseases medicine.disease Comorbidity Cross-Sectional Studies Liver biopsy Insulin Resistance Metabolic syndrome business |
| Zdroj: | Hepatobiliary & Pancreatic Diseases International. 20:426-432 |
| ISSN: | 1499-3872 |
| Popis: | Background This study aimed to assess the association between metabolic syndrome (MetS) and severity of nonalcoholic fatty liver disease (NAFLD), and to discuss the pathological relevance of the diagnostic criteria in metabolic (dysfunction) associated fatty liver disease (MAFLD). Methods This was a multicenter, cross-sectional study. Patients with NAFLD confirmed by liver biopsy were enrolled between July 2016 and December 2018 from 14 centers across the mainland of China. Anthropometric and metabolic parameters were collected to assess the pathological relevance. Results Of 246 enrolled patients with NAFLD, 150 (61.0%) had the comorbidity of MetS. With the increase of metabolic components, the proportions of nonalcoholic steatohepatitis (NASH) and significant fibrosis were notably increased. The comorbid three metabolic components significantly increased the proportion of NASH, and further increase of metabolic components did not increase the proportion of NASH. However, the increase of metabolic components was parallel to the increase of the proportion of liver fibrosis. Among the 246 patients, 239 (97.2%) met the diagnostic criteria of MAFLD. Although non-MAFLD patients had less NASH, they present with similar proportion of significant fibrosis and cirrhosis. In the diagnostic criteria of MAFLD, BMI ≥ 23 kg/m2 was related to NASH (Mantel-Haenszel Common Estimate OR: 2.975; 95% CI: 1.037–8.538; P = 0.043), and T2DM was related to significant fibrosis (Mantel-Haenszel Common Estimate OR: 2.531; 95% CI: 1.388–4.613; P = 0.002). The homeostasis model assessment of insulin resistance (HOMA-IR) ≥ 2.5 was the most significant factor for NASH (OR: 4.100; 95% CI: 1.772–9.487; P = 0.001) and significant factor for liver fibrosis (OR: 2.947; 95% CI: 1.398–6.210; P = 0.004) after the adjustments of the BMI and diabetes. Conclusions Metabolic dysregulations are important risk factors in NAFLD progression. The insulin resistance status may play a predominant role in the progression in MAFLD patients. |
| Databáze: | OpenAIRE |
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