Endothelin induces potent microvascular constriction
| Autor: | J.R. Tippins, S.D. Brain, Timothy J. Williams |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
medicine.hormone
Vasodilation Pharmacology Biology Microcirculation Endothelins In vivo medicine Animals Skin Anatomy Blood flow medicine.anatomical_structure Vasoconstriction cardiovascular system Endothelium Vascular Rabbits medicine.symptom Peptides Endothelin receptor Blood Flow Velocity Research Article circulatory and respiratory physiology Blood vessel |
| Zdroj: | British Journal of Pharmacology. 95:1005-1007 |
| ISSN: | 0007-1188 |
| Popis: | Endothelin is a recently discovered peptide produced by endothelial cells. It has been shown to have potent constrictor effects on major arteries in vitro and to raise rat blood pressure in vivo. The present experiments show that endothelin has a potent constrictor action on the microvasculature. Blood flow changes were measured by a xenon clearance technique in rabbit skin. Endothelin, when injected intradermally into rabbit skin, decreased local blood flow in a dose-dependent manner. Endothelin reduced basal skin blood flow and reversed the increased blood flow induced by a vasodilator. These results show that endothelin, administered extravascularly, has potent vasoconstrictor activity. This adds further support to the suggestion that endothelin may have an important role in the physiological control of blood flow and pressure. |
| Databáze: | OpenAIRE |
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