Metabonomics reveals that triclocarban affects liver metabolism by affecting glucose metabolism, β-oxidation of fatty acids, and the TCA cycle in male mice
| Autor: | Haishan Li, Zhenqing Zhang, Juan Ren, Xiaomei Zhuang, Wenping Xie, Wenpeng Zhang, Wentao Li, Guolin Shen, Mengyang Chang, Huiming Chen |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Triclocarban Citric Acid Cycle Endogeny 010501 environmental sciences Carbohydrate metabolism urologic and male genital diseases Toxicology 01 natural sciences 03 medical and health sciences chemistry.chemical_compound Animals Metabolomics Glycolysis Amino Acids 0105 earth and related environmental sciences Dose-Response Relationship Drug Chemistry Fatty Acids Organ Size General Medicine female genital diseases and pregnancy complications Mice Inbred C57BL Citric acid cycle Metabolic pathway Glucose 030104 developmental biology Liver Gluconeogenesis Biochemistry Anaerobic glycolysis Oxidation-Reduction Carbanilides Metabolic Networks and Pathways |
| Zdroj: | Toxicology Letters. 299:76-85 |
| ISSN: | 0378-4274 |
| DOI: | 10.1016/j.toxlet.2018.09.011 |
| Popis: | This study combined metabonomics with molecular biology techniques to identify differential endogenous substances produced by triclocarban (TCC) that affect plasma and liver metabolism in mice, to map their associated metabolic pathways, and to systematically determine the mechanism of TCC affecting liver metabolism in mice. The results showed that TCC affected liver metabolism by a mechanism involving the inhibition of glucose oxidation in the liver, promotion of anaerobic glycolysis and gluconeogenesis, and accelerated β-oxidation of liver fatty acids and the TCA cycle, which lead to metabolic disorders of the liver microenvironment in mice. The analysis of endogenous substances in the liver and plasma indicated that TCC caused physiological and pathological changes in the liver, and affected the physiological state of mice and the metabolic balance of endogenous substances. Based on metabonomics and bioinformatics analysis methods, this study elucidated a new mechanism involved in how TCC affects liver metabolism. |
| Databáze: | OpenAIRE |
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