An Elderly Woman with Anti-neutrophil Antibody-positive Agranulocytosis Who Responded to High-dose Intravenous Methylprednisolone
| Autor: | Hirohisa Nakamae, Yasuhiro Nakashima, Maiko Kuroda, Takuro Yoshimura, Hideo Koh, Shiro Koh, Takahiko Nakane, Yuki Kubo, Masahiko Ohsawa, Masayuki Hino, Mitsutaka Nishimoto |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Neutropenia medicine.drug_class Case Report 030204 cardiovascular system & hematology Gastroenterology agranulocytosis Methylprednisolone Drug Administration Schedule Antibodies Antineutrophil Cytoplasmic Autoimmune Diseases 03 medical and health sciences Leukocyte Count 0302 clinical medicine Fatal Outcome Internal medicine Granulocyte Colony-Stimulating Factor Internal Medicine medicine Humans anti-neutrophil antibody Treatment Failure Glucocorticoids Anti-neutrophil cytoplasmic antibody Aged business.industry General Medicine medicine.disease Granulocyte colony-stimulating factor Discontinuation high-dose methylprednisolone Etiology Absolute neutrophil count Corticosteroid Administration Intravenous Female business 030215 immunology medicine.drug |
| Zdroj: | Internal Medicine |
| ISSN: | 1349-7235 0918-2918 |
| Popis: | Although anti-neutrophil antibodies (ANAs) often exist and immunoreaction may be involved in agranulocytosis, few reports have so far described ANA-positive cases of agranulocytosis with an unknown etiology. We herein describe the case of a 69-year-old woman who presented with ANA-positive agranulocytosis. In this case, both the withdrawal of the drugs that had possibly caused neutropenia and the use of granulocyte-colony stimulating factor (G-CSF) were ineffective treatment measures. Approximately 2 weeks after the discontinuation of the suspected drugs, we initiated corticosteroid pulse therapy; the neutrophil count recovered by day 19 of steroid therapy. High-dose methylprednisolone therapy should thus be considered for patients demonstrating ANA-positive agranulocytosis with an unknown etiology that is refractory to G-CSF treatment. |
| Databáze: | OpenAIRE |
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