Hepatic lipase gene expression is upregulated by a cystine-rich diet in male but not in female rats
| Autor: | S. Griglio, Jacqueline Férézou, Marie lrène Malewiak, Colette Sérougne, Dominique Lagrange, Ferdaous Benhizia |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Male
medicine.medical_specialty Hypercholesterolemia Biophysics Cystine Gene Expression Biology Biochemistry chemistry.chemical_compound Sex Factors Endocrinology Downregulation and upregulation Internal medicine Male rats Gene expression medicine Animals RNA Messenger Rats Wistar Lipoprotein lipase Cholesterol Cholesterol HDL Lipase Diet Rats Up-Regulation Liver chemistry Female Hepatic lipase Lipoprotein |
| Zdroj: | Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism. 1255:50-56 |
| ISSN: | 0005-2760 |
| DOI: | 10.1016/0005-2760(94)00208-g |
| Popis: | Male and female rats fed a cystine-rich diet (5% l-cystine) became hypercholesterolemic after 2 months, with 2-fold higher cholesterol levels carried mainly by the HDL1 and HDL2 lipoprotein fractions. Post-heparin lipoprotein lipase activity was increased in male rats only (60%, P < 0.01), while hepatic lipase (HL) activity was increased in both males and females (48%, P < 0.001 and 27%, P < 0.01, respectively). In the liver, HL activity and mRNA levels were increased in males (30%, P < 0.01, and 70%, P < 0.001, respectively), but not in females. A higher correlation between HDL1-cholesterol and liver, HL activity was found in male rats than in female rats. In the latter, although the cystine diet induced a virtually identical increase in HDL1-cholesterol, HL gene expression was not promoted. It is suggested that HL gene expression may be triggered by the uptake of HDL1-cholesterol in male rats, while oestrogens in female rats would counteract this effect. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect