Post-COVID-19 symptoms 6 months after acute infection among hospitalized and non-hospitalized patients

Autor: Alvisa Palese, Francesco Curcio, Carlo Tascini, Martina Fabris, Margherita Venturini, Miriam Isola, Valentina Gerussi, Maddalena Peghin, Francesco Marrella, Giulia Bontempo, Alberto Tommasini, Maria De Martino, Elena Graziano
Přispěvatelé: Peghin, M., Palese, A., Venturini, M., De Martino, M., Gerussi, V., Graziano, E., Bontempo, G., Marrella, F., Tommasini, A., Fabris, M., Curcio, F., Isola, M., Tascini, C.
Jazyk: angličtina
Rok vydání: 2021
Předmět:
0301 basic medicine
Male
Hospitalized patients
Acute infection
COVID survivors
Disease
Antibodies
Viral
Serology
0302 clinical medicine
Chronic COVID
COVID-19
Long COVID
Patients with post-COVID-19 syndrome
Post-COVID syndrome
SARS-CoV-2 antibodies
SARS-CoV-2 serology
Adolescent
Adult
Aged
Female
Follow-Up Studies
Humans
Immunoglobulin G
Italy
Middle Aged
Prevalence
Prospective Studies
Risk Factors
SARS-CoV-2
Young Adult
030212 general & internal medicine
Viral
Prospective cohort study
COVID survivor
biology
General Medicine
Icu admission
Infectious Diseases
SARS-CoV-2 antibodie
Original Article
Antibody
Human
Microbiology (medical)
medicine.medical_specialty
Coronavirus disease 2019 (COVID-19)
030106 microbiology
Lasting haulers
Antibodies
Follow-Up Studie
03 medical and health sciences
Post-Acute COVID-19 Syndrome
Internal medicine
medicine
business.industry
Risk Factor
Prospective Studie
biology.protein
business
Zdroj: Clinical Microbiology and Infection
Popis: Objectives To assess the prevalence of and factors associated with post-coronavirus disease 2019 (COVID-19) syndrome 6 months after the onset. Methods A bidirectional prospective study. Interviews investigated symptoms potentially associated with COVID-19 6 months after the disease onset of all consecutive adult inpatients and outpatients with COVID-19 attending Udine Hospital (Italy) from March to May 2020. IgG antibodies against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) were also evaluated 6 months after the onset of symptoms, at the time of the interview. Results A total of 599 individuals were included (320 female, 53.4%; mean age 53 years, SD 15.8) and interviewed 187 days (22 SD) after onset. The prevalence of post-COVID-19 syndrome was 40.2% (241/599). The presence of IgG antibodies was significantly associated with the occurrence of post-COVID-19 syndrome (OR 2.56, 95% CI 1.48–4.38, p 0.001) and median SARS-CoV-2 IgG titres were significantly higher in patients with post-COVID-19 syndrome than in patients without symptoms (42.1, IQR 17.1–78.4 vs. 29.1, IQR 12.1–54.2 kAU/L, p 0.004). Female gender (OR 1.55, 95% CI 1.05–2.27), a proportional increase in the number of symptoms at the onset of COVID-19 (OR 1.81, 95% CI 1.59–2.05) and ICU admission OR 3.10, 95% CI 1.18–8.11) were all independent risk factors for post-COVID-19 syndrome. The same predictors also emerged in a subgroup of 231 patients with the serological follow-up available at the time of the interview alongside the proportional increase in anti-SARS-CoV-2 IgG (OR 1.01, 95% CI 1.00–1.02, p 0.04). Discussion Prospective follow-up could be offered to specific subgroups of COVID-10 patients, to identify typical symptoms and persistently high anti-SARS-CoV-2 IgG titres as a means of early detection of post-COVID-19 long-term sequelae.
Databáze: OpenAIRE
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