Severity modeling of propionic acidemia using clinical and laboratory biomarkers

Autor: Susan Ferry, Oleg A Shchelochkov, Olivia Wenger, Paul Juneau, Samantha McCoy, Jeffrey B. Kopp, Mark D. Levin, Charles P. Venditti, Alexandra Pass, Irini Manoli, Laryssa A. Huryn, Megan Schoenfeld, Joseph Snow, Audrey Thurm, Colby Chlebowski, Wadih M. Zein, Kong Y. Chen, Jennifer L. Sloan, Jennifer Myles, Carol Van Ryzin
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Genetics in Medicine
ISSN: 1530-0366
1098-3600
Popis: To conduct a proof-of-principle study to identify subtypes of propionic acidemia (PA) and associated biomarkers. Data from a clinically diverse PA patient population ( https://clinicaltrials.gov/ct2/show/NCT02890342 ) were used to train and test machine learning models, identify PA-relevant biomarkers, and perform validation analysis using data from liver-transplanted participants. k-Means clustering was used to test for the existence of PA subtypes. Expert knowledge was used to define PA subtypes (mild and severe). Given expert classification, supervised machine learning (support vector machine with a polynomial kernel, svmPoly) performed dimensional reduction to define relevant features of each PA subtype. Forty participants enrolled in the study; five underwent liver transplant. Analysis with k-means clustering indicated that several PA subtypes may exist on the biochemical continuum. The conventional PA biomarkers, plasma total 2-methylctirate and propionylcarnitine, were not statistically significantly different between nontransplanted and transplanted participants motivating us to search for other biomarkers. Unbiased dimensional reduction using svmPoly revealed that plasma transthyretin, alanine:serine ratio, GDF15, FGF21, and in vivo 1-13C-propionate oxidation, play roles in defining PA subtypes. Support vector machine prioritized biomarkers that helped classify propionic acidemia patients according to severity subtypes, with important ramifications for future clinical trials and management of PA.
Databáze: OpenAIRE
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