Implantable system for chronotherapy
| Autor: | Seung Ho Lee, Ameya R. Kirtane, Hen-Wei Huang, Qianqian Wan, Joy Collins, Hyunjoon Kim, Ian Ballinger, SeJun Lee, Siddartha Tamang, Wei Chen, Canchen Li, George Selsing, Keiko Ishida, Adam J Wentworth, Kaitlyn Wong, Aaron Lopes, Robert Langer, Stephen T. Buckley, Giovanni Traverso, Alison Hayward, Kaitlyn Hess, Jung Seung Lee |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Science Advances |
| ISSN: | 2375-2548 |
| Popis: | Description A mobile app–controlled implantable system enables chronotherapy by controlling the timing of drug administration. Diurnal variation in enzymes, hormones, and other biological mediators has long been recognized in mammalian physiology. Developments in pharmacobiology over the past few decades have shown that timing drug delivery can enhance drug efficacy. Here, we report the development of a battery-free, refillable, subcutaneous, and trocar-compatible implantable system that facilitates chronotherapy by enabling tight control over the timing of drug administration in response to external mechanical actuation. The external wearable system is coupled to a mobile app to facilitate control over dosing time. Using this system, we show the efficacy of bromocriptine on glycemic control in a diabetic rat model. We also demonstrate that antihypertensives can be delivered through this device, which could have clinical applications given the recognized diurnal variation of hypertension-related complications. We anticipate that implants capable of chronotherapy will have a substantial impact on our capacity to enhance treatment effectiveness for a broad range of chronic conditions. |
| Databáze: | OpenAIRE |
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