Body composition in young patients with galactose metabolic disorders: a preliminary report
| Autor: | Artemis Doulgeraki, Kleopatra H. Schulpis, Ioannis Monopolis, Domna Deligianni, Maria Kalogerakou |
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| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Endocrinology Diabetes and Metabolism Overweight Carbohydrate metabolism chemistry.chemical_compound Absorptiometry Photon Endocrinology Preliminary report Internal medicine medicine Humans Child Bone mineral business.industry Galactosemia Galactose medicine.disease chemistry Biochemistry Pediatrics Perinatology and Child Health Body Composition Female Composition (visual arts) medicine.symptom business Body mass index Carbohydrate Metabolism Inborn Errors |
| Zdroj: | Journal of Pediatric Endocrinology and Metabolism. 27 |
| ISSN: | 2191-0251 0334-018X |
| DOI: | 10.1515/jpem-2013-0161 |
| Popis: | Aim Body composition evaluation in patients with galactosemia and its variants. Methods The body composition of young subjects with galactose metabolic disorders was analyzed with dual X-ray absorptiometry. The subjects were divided into the classic galactosemia (CG; n=14) group and the group with other galactose metabolic disorders (OGMD, e.g., epimerase deficiency; n=8). Results In both groups, bone strength and bone mineral density Z-scores were normal. However, CG patients appeared sarcopenic (median muscle mass Z-score=-1.93), whereas OGMD subjects had low-normal muscle mass. In addition, approximately half of all patients were overweight. In CG patients, bone mass was strongly correlated to muscle mass (r=0.81), whereas in OGMD patients it was positively correlated to body mass index (r=0.78). Conclusions An imbalance between muscle and fat mass, especially in patients with classic galactosemia, was observed. Given the observed strong correlation between bone and muscle mass, more effective lifestyle counseling is needed. |
| Databáze: | OpenAIRE |
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