Oral pilocarpine for the treatment of ocular symptoms in patients with Sjogren's syndrome: a randomised 12 week controlled study
| Autor: | C A Paschides, V Eftaxias, Alexandros A. Drosos, Paraskevi V. Voulgari, K Psilas, Niki Tsifetaki, Yannis Alamanos, G Kitsos |
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| Rok vydání: | 2003 |
| Předmět: |
genetic structures
Visual analogue scale Nausea Pilocarpine/*administration & dosage/adverse effects medicine.medical_treatment Eye disease Immunology Administration Oral General Biochemistry Genetics and Molecular Biology Rheumatology Occlusion medicine Humans Immunology and Allergy Blepharitis Sjogren's Syndrome/*drug therapy business.industry Pilocarpine Miotics/*administration & dosage/adverse effects Middle Aged medicine.disease eye diseases Extended Report stomatognathic diseases Artificial tears Sjogren's Syndrome Ophthalmic Solutions/administration & dosage Anesthesia Vomiting Female Ophthalmic Solutions medicine.symptom business Miotics medicine.drug |
| Zdroj: | Annals of the Rheumatic Diseases. 62:1204-1207 |
| ISSN: | 0003-4967 |
| DOI: | 10.1136/ard.2002.003889 |
| Popis: | OBJECTIVE: To evaluate the efficacy and side effects of oral pilocarpine for the treatment of ocular symptoms in patients with primary Sjogren's syndrome (SS). METHODS: A 12 week, single centre, randomised controlled study was performed. Twenty nine patients were randomly assigned to receive oral pilocarpine (5 mg twice a day), 28 only artificial tears, and 28 inferior puncta occlusion. Patients receiving oral pilocarpine and those with inferior puncta occlusion also received artificial tears. Patients were evaluated at baseline and throughout the study for their subjective global assessment of dry eyes and for their objective assessment of dry eyes (Schirmer's-I test, rose bengal test, and imprint test). RESULTS: Patients taking oral pilocarpine had significant improvement in subjective global assessment of dry eyes, as was evaluated by improvement of >55 mm on a visual analogue scale (VAS) for responses to the eye questionnaire, compared with patients treated with artificial tears (p55 mm on a VAS. Additionally, an improvement of rose bengal staining was noted, but an increase in tear production, as measured by the Schirmer-I test, was not substantiated. Ann Rheum Dis |
| Databáze: | OpenAIRE |
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