Water-Soluble Iridium Photoredox Catalyst for the Trifluoromethylation of Biomolecule Substrates in Phosphate Buffered Saline Solvent
| Autor: | Jay Conrad, Nicholas S. Settineri, Connor J O'Brien, Nick A. Paras, Steven H. Olson, Terrence-Thang H Nguyen, Stanley B. Prusiner, Minh L N Tran |
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| Rok vydání: | 2021 |
| Předmět: |
Hydrocarbons
Fluorinated Light chemistry.chemical_element Peptide 010402 general chemistry Iridium 01 natural sciences Biochemistry Catalysis Phosphates Microtiter plate Physical and Theoretical Chemistry chemistry.chemical_classification Mesylates Molecular Structure 010405 organic chemistry Trifluoromethylation Biomolecule Organic Chemistry Water 0104 chemical sciences Solvent chemistry Reagent Solvents Nuclear chemistry |
| Zdroj: | Organic letters. 23(10) |
| ISSN: | 1523-7052 |
| Popis: | The development of a water-soluble iridium catalyst enables the trifluoromethylation of polar small molecules and peptides in DMSO solution or aqueous media. The reaction was optimized in a microtiter plate format under ambient air, using commercial Langlois reagent as a CF3 radical source, blue LEDs for excitation, and using DPBS as solvent to provide up to 60% CF3- peptide. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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