Photoreactivating enzyme from Streptomyces griseus-IV. On the nature of the chromophoric cofactor in Streptomyces griseus photoreactivating enzyme
| Autor: | W. Berends, R. H. Dekker, André P. M. Eker |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Chemical Phenomena
Stereochemistry Photochemistry Lyases Pyrimidine dimer Biochemistry Cofactor chemistry.chemical_compound Physical and Theoretical Chemistry Blue light chemistry.chemical_classification biology Chemistry Chromogenic Streptomyces griseus General Medicine biology.organism_classification Enzyme Pyrimidine Dimers biology.protein Photoreactivating enzyme Deoxyribodipyrimidine Photo-Lyase Derivative (chemistry) |
| Zdroj: | Photochemistry and photobiology. 33(1) |
| ISSN: | 0031-8655 |
| Popis: | — A structure for the chromophoric part of the intrinsic cofactor of Streptomyces griseus photo-reactivating enzyme is suggested on the basis of absorption and fluorescence spectra of cofactor and reference compounds at various pH. The essential chromogenic part of this cofactor is proposed to be a 7,8-didemethy]-8-hydroxy-5-deazaflavin derivative (Ia). From whole S. griseus cells a compound SF420 (Ic) was isolated which contains the same chromophoric group. This compound sensitizes the splitting of thymine dimers when irradiated with blue light, supporting the structure proposed for the photoreactivating enzyme cofactor. |
| Databáze: | OpenAIRE |
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