Extrinsic lactose fines improve dry powder inhaler formulation performance of a cohesive batch of budesonide via agglomerate formation and consequential co-deposition
| Autor: | Deborah Huck, Robert Price, Hanne Kinnunen, Lisa Makein, Harry Peters, Gerald Hebbink |
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| Rok vydání: | 2015 |
| Předmět: |
Budesonide
Drug deposition Chemistry Chemistry Pharmaceutical Pharmaceutical Science Capsules Dry Powder Inhalers Co deposition Lactose Dry-powder inhaler Bronchodilator Agents chemistry.chemical_compound Crystallography Dry powder inhaler Hypromellose Derivatives Chemical engineering Agglomerate medicine Raman spectroscopy Particle Particle Size medicine.drug Particle fraction |
| Zdroj: | International journal of pharmaceutics, 2015, Vol.478(1), pp.53-59 [Peer Reviewed Journal] |
| DOI: | 10.1016/j.ijpharm.2014.11.019 |
| Popis: | The aim of the study was to investigate how the fine particle content of lactose carriers prepared with different types of lactose fines regulates dry powder inhaler (DPI) formulation performance of a cohesive batch of micronised budesonide. Budesonide formulations (0.8 wt-% ) were prepared with three different lactose carriers (Lactohale (LH) LH100, 20 wt-% LH210 in LH100 and 20 wt-% LH300 in LH100). Fine particle fraction of emitted dose (FPFED) and mean mass aerodynamic diameter (MMAD) of budesonide was assessed with a Next Generation Impactor (NGI) using a Cyclohaler at 90 l/min. Morphological and chemical characteristics of particles deposited on Stage 2 were determined using a Malvern Morphologi G3-ID. The results indicate that increasing concentration of lactose fines ( |
| Databáze: | OpenAIRE |
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