Supplementary Figures 1 - 6 from NF-κB Activation-Induced Anti-apoptosis Renders HER2-Positive Cells Drug Resistant and Accelerates Tumor Growth

Autor: Debajit K. Biswas, J. Dirk. Iglehart, Myles Brown, Alexander Miron, Teresa Bowman, Kathleen M. Foley, Ruiyang Tian, Scott. J. Rodig, Gautam Maulik, Bose Kochupurakkal, Yoon J. Choi, Penelope L. Miron, Shannon T. Bailey
Rok vydání: 2023
DOI: 10.1158/1541-7786.22509954
Popis: PDF file - 669K, Figure S1. FACS sorting of HER2-enriched fraction of SKBR3 and analysis of same by FACS in parental derivatives. Figure S2. Inhibition of HER2 signaling by Lapatinib in SKR6 and SKR6LR cells. Figure S3. Xenograft histopathology. Figure S4. NF-κB DNA binding activity by electrophoretic mobility shift assay (EMSA). Figure S5. Geno Ontology (GO) terms for genes found in clusters II, III and IV from Figure 5B. Figure S6. Hypothesis: Constitutive activation of NF-kB accelerates tumor growth by evading drug sensitivity resulting in poor clinical outcome.
Databáze: OpenAIRE