| Autor: |
Juliana Damieli Nascimento, Encarni Marcos, Sergio Ruschi, Marcelo N. Costa, Luís Fernando Tófoli, Eduardo Bouth Sequerra, César Rennó-Costa, Isis M. Ornelas, Stevens K. Rehen, Amanda Feilding, Draulio de Araujo, Daniel Martins-de-Souza, Sidarta Ribeiro, Livia Goto-Silva, Karina Karmirian, Felipe Augusto Cini, José Alexandre Salerno |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
|
| DOI: |
10.1101/866814 |
| Popis: |
Psychedelic agonists of serotonin receptors induce neural plasticity and synaptogenesis, but their potential to enhance learning remains uncharted. Here we show that a single dose of d-LSD, a potent serotonergic agonist, increased novel object preference in young and adult rats several days after treatment. d-LSD alone did not increase preference in old animals, but could rescue it to young levels when followed by a 6-day exposure to enriched environment (EE). Mass spectrometry-based proteomics in human brain organoids treated with d-LSD showed upregulation of proteins from the presynaptic active zone. A computational model of synaptic connectivity in the hippocampus and prefrontal cortex suggests that d-LSD enhances novelty preference by combining local synaptic changes in mnemonic and executive regions, with alterations of long-range synapses. Better pattern separation within EE explained its synergy with d-LSD in rescuing novelty preference in old animals. These results advance the use of d-LSD in cognitive enhancement. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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