Spinal imaging features in Japanese patients with Marfan syndrome: a case-control study
| Autor: | Hideaki Yuki, Akira Sasao, Seitaro Oda, Daisuke Utsunomiya, Toshinori Hirai, Tsuyoshi Yasuda, Yasuyuki Yamashita, Eri Hayashida, Akihiko Arakawa, Joji Urata |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male musculoskeletal diseases Marfan syndrome congenital hereditary and neonatal diseases and abnormalities medicine.medical_specialty Lumbosacral spine Sensitivity and Specificity Marfan Syndrome Young Adult Japan medicine Humans Radiology Nuclear Medicine and imaging skin and connective tissue diseases Spinal imaging Aged Retrospective Studies Lumbar Vertebrae integumentary system medicine.diagnostic_test business.industry Dural ectasia Case-control study Magnetic resonance imaging Retrospective cohort study Anatomy Middle Aged musculoskeletal system medicine.disease Magnetic Resonance Imaging Spine Vertebral body Case-Control Studies Female Radiology Tomography X-Ray Computed business |
| Zdroj: | Japanese Journal of Radiology. 32:205-210 |
| ISSN: | 1867-108X 1867-1071 |
| Popis: | The purpose of our study was to evaluate the morphology of the lumbosacral spine, i.e. the dura and vertebral body shape, of Japanese patients with Marfan syndrome (MFS) by comparing it with sex- and age-matched controls.Spinal MR or CT images of 32 MFS patients and 32 controls were retrospectively reviewed. The anteroposterior dural sac diameter (DSD), anteroposterior vertebral body diameter (VBD), and vertebral body height (VBH) were measured from L1 to S1 levels and the dural sac ratio [DSR = (DSD/VBD)] and vertebral body aspect ratio [VAR = (VBH/VBD)] were calculated.At each level, mean DSD and DSR were significantly higher in MFS patients; VBD was not. The cutoff values for DSR to differentiate between MFS patients and the controls were 0.59, 0.46, 0.42, 0.45, 0.47, and 0.47 from the level of L1 to S1. At a sensitivity of 93.8 % and a specificity of 84.4 % the cutoff value at S1 was most diagnostic. In MFS patients VAR was significantly higher at L3 and L4.Our cutoff value for DSR0.47 at S1 may help to identify MFS in the Japanese population. A square-like appearance of the L3 and L4 vertebral bodies is a supplementary finding in MFS patients. |
| Databáze: | OpenAIRE |
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