S-25-hydroxyvitamin D and C3-epimers in pregnancy and infancy:An Odense child cohort study
| Autor: | Sine Lykkedegn, Nanne Dreier Mydtskov, Palle Back Nielsen Fruekilde, Jan Nielsen, Torben Barington, Henrik Thybo Christesen |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
Vitamin D/analogs & derivatives Fetal Blood/metabolism Clinical Biochemistry Maternal 030204 cardiovascular system & hematology Longitudinal Course Cohort Studies 0302 clinical medicine Pregnancy Tandem Mass Spectrometry Background analysis Medicine Vitamin D C3-epi-25-hydroxyvitamin D Child education.field_of_study Hydroxycholecalciferols Vitamins General Medicine Fetal Blood Cord Child Preschool Cohort Female Maternal vitamin Cohort study medicine.medical_specialty Population Calcifediol/metabolism 030209 endocrinology & metabolism 25-Hydroxyvitamin D 03 medical and health sciences Vitamin D Deficiency/blood Internal medicine Hydroxycholecalciferols/blood Vitamin D and neurology Journal Article Humans LC-MS/MS education Vitamins/blood Calcifediol business.industry Infant Vitamin D Deficiency medicine.disease Endocrinology Dietary Supplements business Chromatography Liquid |
| Zdroj: | Dreier Mydtskov, N, Lykkedegn, S, Fruekilde, P B N, Nielsen, J, Barington, T & Christesen, H T 2017, ' S-25-hydroxyvitamin D and C3-epimers in pregnancy and infancy : An Odense child cohort study ', Clinical Biochemistry, vol. 50, no. 18, pp. 988-996 . https://doi.org/10.1016/j.clinbiochem.2017.07.001 |
| DOI: | 10.1016/j.clinbiochem.2017.07.001 |
| Popis: | BACKGROUND: Analysis of serum 25-hydroxyvitamin D (s-25(OH)D) may be complicated by the less active or in-active vitamin D metabolite C3-epi-25(OH)D 3 (C3-epimer). We aimed to explore the relationship between s-C3-epimer and s-25(OH)D and other determinants and describe the longitudinal course of the C3-epimer fraction in paired mother-child samples. METHOD: S-25(OH)D and s-C3-epimer were estimated by liquid chromatography mass spectrometry in 290 mother-infant pairs from the population-based Odense Child Cohort. Longitudinal analyses were feasible in two subcohorts; B) early and late pregnancy, cord, three and 18months (n=132); and C) early and late pregnancy, delivery and cord (n=105).RESULTS: Mean s-25(OH)D was 50.6-110.4nmol/L at the six time points. The mean C3-epimer fraction was 10.1% at three months, 1.1%-3.0% at the other time points. In multivariate analyses, the s-C3-epimer correlated with s-25(OH)D (all time points, pCONLCUSION: The s-C3-epimer was independently correlated to s-25(OH)D, season, maternal vitamin D supplementation, maternal and infant age. The C3-epimer fraction was only of clinical importance in early infancy, where it could lead to misclassification of the vitamin D status. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|