The impact of an ultra-trail on the dynamic of cardiac, inflammatory, renal and oxidative stress biological markers correlated with electrocardiogram and echocardiogram
| Autor: | Pierre Melon, Raluca Elena Dulgheru, Etienne Cavalier, J-F Kaux, Joël Pincemail, C. Le Goff, Laurence Seidel |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
medicine.medical_specialty medicine.drug_class Diastole 030204 cardiovascular system & hematology Left ventricular hypertrophy medicine.disease_cause Electrocardiography 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Troponin T Internal medicine Natriuretic peptide medicine Humans 030212 general & internal medicine Creatinine biology business.industry General Medicine Middle Aged medicine.disease Oxidative Stress Cystatin C chemistry Echocardiography biology.protein Cardiology Creatine kinase Cardiology and Cardiovascular Medicine business Biomarkers Oxidative stress |
| Zdroj: | Acta Cardiologica. 76:739-747 |
| ISSN: | 0373-7934 0001-5385 |
| Popis: | The aim of this study was to describe the effects of a 64.2 km ultra-trail on the biomarkers of muscle damage, inflammation and oxidative stress, and compare the results observed with an ECG and an echocardiogram, both performed before and after the race.Thirty-three ultra-trail volunteers (45.8 ± 8.7 years old) were enrolled in our study. Three blood tests were drawn from each runner, one just before (TPRE), one just after (TPOST) and the last 3 h after the end of the race (TPOST3h).All the markers increased. The maximum concentrations observed were at TPOST3h and were significant (p < 0.001) for creatine kinase, creatine kinase isoform MB, high-sensitivity C-reactive protein, uric acid and for the ratio of reduced glutathione to oxidised glutathione. However, in the case of myoglobin, high-sensitive troponin T, N-terminal pro-brain natriuretic peptide, oxidised glutathione, myeloperoxidase, cystatin C and creatinine, the most significant increases were at TPOST (p < 0.001). Modifications were observed in the medical imaging using echocardiography such as reduction of left ventricule end-sytolic and diastolic volumes and left ventricular global longitudinal strain. ECG showed electrical criteria for left ventricular hypertrophy and incomplete right bundle branch block after the race.Endurance races cause significant physiological stress to the body that can be measured by the increase of different biomarkers. From a laboratory perspective, it is important to take into account the possible exercise performed previous to the testing to avoid a misinterpretation of the results. From a training perspective, due to these increases in biomarkers, it is recommended that runners wait at least 72 h after an ultra-trail before subsequent training. In addition a transient impairment of ventricular function due to dehydration were observed. |
| Databáze: | OpenAIRE |
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