Safety and efficacy of multiple cyclocoagulation of ciliary bodies by high-intensity focused ultrasound in patients with glaucoma
| Autor: | Emilio Pedrotti, Giulia Stevan, Alessandra De Gregorio, Margherita Montali, Simonetta Morselli |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Intraocular pressure Visual acuity genetic structures medicine.medical_treatment Visual Acuity Glaucoma ciliary body cyclocoagulation glaucoma glaucoma procedure high-intensity focused ultrasound non invasive therapy 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Ciliary body medicine Glaucoma surgery Humans Prospective Studies Prospective cohort study Antihypertensive Agents Intraocular Pressure Aged Aged 80 and over business.industry Middle Aged medicine.disease eye diseases Sensory Systems High-intensity focused ultrasound Surgery Ophthalmology medicine.anatomical_structure Treatment Outcome 030221 ophthalmology & optometry High-Intensity Focused Ultrasound Ablation Female sense organs medicine.symptom business 030217 neurology & neurosurgery Case series Follow-Up Studies |
| Popis: | To evaluate long-term efficacy and safety of repeated ultrasonic circular cyclocoagulation (UCCC) in patients with uncontrolled glaucoma. Forty eyes of 40 patients affected by primary or secondary uncontrolled glaucoma under maximal tolerated medical therapy were enrolled in this prospective non-comparative case series study. A complete ophthalmic examination was performed before and after each month for 1 year. The UCCC treatment was repeated at 4 months if the intraocular pressure (IOP) was > 21 mmHg without major complications. Complete success was defined as a final IOP > 5 mmHg and ≤ 21 mmHg without hypotensive medication adjunction and no major or vision-threatening complications. The mean preoperative IOP was 32.5 ± 9.9 mmHg. Four months after the first UCCC treatment the overall IOP reduction was 27.8%. Twenty-two of the treated eyes did not achieve the complete success and a second treatment was performed in 20 of these eyes. Four months after the second UCCC procedure, the IOP reduction was 20.3% from preoperative values and 34.7% from baseline. Twelve of the retreated eyes needed a third treatment. Four months after the third UCCC treatment, the overall IOP reduction was 34% and 52.6% from baseline. No major complications occurred during or after any of the procedures. At 12 months, complete success was achieved in 85% (34/40) of treated eyes, with a maximum of three procedures and a significant medication reduction. Multiple UCCC treatments are safe, and additional treatments increase the overall procedure efficacy. |
| Databáze: | OpenAIRE |
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