Lymphoma risks in patients with rheumatoid arthritis treated with biological drugs—a Swedish cohort study of risks by time, drug and lymphoma subtype
| Autor: | Johan Askling, Christer Sundström, Karin E. Smedby, Daniela Di Giuseppe, Eva Baecklund, Karin Hellgren |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Lymphoma medicine.medical_treatment Population Comorbidity Risk Assessment Arthritis Rheumatoid Cohort Studies 03 medical and health sciences 0302 clinical medicine Rheumatology Internal medicine medicine Humans Pharmacology (medical) Registries Correlation of Data education 030304 developmental biology Sweden 030203 arthritis & rheumatology Biological Products 0303 health sciences education.field_of_study Duration of Therapy Proportional hazards model business.industry Incidence Hazard ratio Middle Aged medicine.disease TNF inhibitor Antirheumatic Agents Rheumatoid arthritis Cohort Female Tumor Necrosis Factor Inhibitors business Cohort study |
| Zdroj: | Rheumatology. 60:809-819 |
| ISSN: | 1462-0332 1462-0324 |
| Popis: | Objectives To estimate the association between biological DMARDs (bDMARDs; overall and by drug) as used in RA and the risk of malignant lymphomas including subtypes. Methods By linking nationwide Swedish registers we identified cohorts of patients with RA initiating treatment with a bDMARD (n = 16 392), bDMARD-naïve (n = 55 253), an age- and sex-matched general population comparator cohort (n = 229 047), and all incident lymphomas 2001–16. We used Cox regression to calculate hazard ratios (HRs) of lymphoma taking calendar period and other factors into account. Results There were 82 lymphomas among the bDMARD-treated patients with RA, crude incidence rate 76/100 000 person-years, and 310 lymphomas among the bDMARD-naïve patients with RA, crude incidence rate 90/100 000 person-years. This resulted in an adjusted HR (aHR) associated with bDMARD treatment (vs not) of 1.08 (95% CI: 0.83, 1.41). The corresponding aHR for bDMARD-treated and bDMARD-naïve vs the general population was 1.65 (95% CI: 1.31, 2.08) and 1.56 (95% CI: 1.37, 1.78) respectively. Restricting follow-up period to after 2006, the aHR of lymphoma for patients with RA starting a first bDMARD vs bDMARD-naïve was 0.69 (95% CI: 0.47, 1.00), and for bDMARD treated vs patients with RA switching from one conventional synthetic DMARDs to another, aHR was 0.46 (95% CI: 0.28, 0.73). There were no signals of different risks with any particular TNF inhibitor (TNFi) agent. We found no different lymphoma subtype pattern following bDMARD therapy. Conclusion Treatment with bDMARDs, including both TNFi and non-TNFi bDMARDs, does not further increase the lymphoma risk in RA; instead, bDMARD treatment may actually reduce the excess lymphoma risk in RA. |
| Databáze: | OpenAIRE |
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