Sulfite Oxidase Is a Novel Prognostic Biomarker of Advanced Gastric Cancer
| Autor: | Haruhiko Cho, Eiji Sadashima, Yuta Yano, Yoshiki Naito, Jun Akiba, Tsunekazu Hishima, Hirohisa Yano |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty Prognostic factor Multivariate analysis General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound Stomach Neoplasms Sulfite oxidase Internal medicine medicine Overall survival Biomarkers Tumor Humans Prognostic biomarker Pharmacology business.industry Sulfite Oxidase Cancer Advanced gastric cancer medicine.disease Prognosis chemistry immunohistochemistry Immunohistochemistry Gastric cancer business Biomarkers Research Article |
| Zdroj: | In Vivo In Vivo 35(1):229-237, 2021 |
| DOI: | 10.21873/invivo.12251 |
| Popis: | Background/Aim: Sulfite oxidase (SUOX) is an enzyme present in the mitochondria, which has been demonstrated to be correlated with various malignant tumours. Materials and Methods: We evaluated SUOX expression in tissues of 98 cases of advanced gastric cancer and performed a clinicopathological assessment for metrics. Results: Among 98 cases, 55 cases were classified into the SUOX low expression group, and 43 cases into the SUOX high expression group. There were more pStage IV cases in the low expression group. The median overall survival of the low expression group was shorter than that of the high expression group (p=0.020). In univariate and multivariate analysis, SUOX low expression level (p=0.039) and pStage (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|