Global Expression Analysis of Extracellular Matrix–Integrin Interactions in Monocytes
| Autor: | Antonin R. de Fougerolles, Gloria Chi-Rosso, Adriana Bajardi, Philip Gotwals, Cynthia D. Green, Victor E. Koteliansky |
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| Rok vydání: | 2000 |
| Předmět: |
Integrins
Integrin Immunology Monocytes Cell Line Extracellular matrix Gene expression Cell Adhesion Humans Immunology and Allergy Growth Substances Regulation of gene expression biology Janus kinase 1 Gene Expression Profiling NF-kappa B Janus Kinase 1 Protein-Tyrosine Kinases Molecular biology Extracellular Matrix Fibronectins Cell biology DNA-Binding Proteins Gene expression profiling STAT1 Transcription Factor Infectious Diseases Gene Expression Regulation Cell culture Trans-Activators biology.protein Signal transduction Signal Transduction |
| Zdroj: | Immunity. 13(6):749-758 |
| ISSN: | 1074-7613 |
| DOI: | 10.1016/s1074-7613(00)00073-x |
| Popis: | Central to immune and inflammatory responses are the integrin-mediated adhesive interactions of cells with their extracellular matrix (ECM)-rich environment. Using a comprehensive and quantitative mRNA profiling technique, we analyzed the effect of ECM-induced attachment on monocyte gene expression, its regulation by growth factors, and the integrin specificity of this event. Adhesion of cells to fibronectin resulted in increased expression of a large number of genes, which was strongly potentiated by the presence of growth factors. Adhesion activated both the NF-κB and Jak/STAT pathways of gene transcription and increased expression of genes involved in inflammatory and immune responses, revealing the importance of ECM–integrin interactions in these processes. |
| Databáze: | OpenAIRE |
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