Gemcitabine in the second-line therapy of patients with carcinoma of unknown primary site: a phase II trial of the Minnie Pearl Cancer Research Network

Autor:	Howard A. Burris, F. Anthony Greco, Jane Bramham, Sharon Calvert, Daniel C. Scullin, John D. Hainsworth, Noel T. Willcutt
Rok vydání:	2001
Předmět:	Oncology Adult Male Cancer Research medicine.medical_specialty Antimetabolites Antineoplastic medicine.medical_treatment Treatment outcome Salvage therapy Adenocarcinoma Deoxycytidine Disease-Free Survival Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Carcinoma Humans Infusions Intravenous Aged Salvage Therapy Second-line therapy Chemotherapy business.industry General Medicine Leukopenia Middle Aged medicine.disease Thrombocytopenia Gemcitabine Surgery Treatment Outcome Drug Resistance Neoplasm Unknown primary Neoplasms Unknown Primary Female Previously treated business medicine.drug
Zdroj:	Cancer investigation. 19(4)
ISSN:	0735-7907
Popis:	The purpose of this study was to evaluate the activity of single-agent gemcitabine in previously treated patients with carcinoma of unknown primary site. Between January 1997 and October 1998, 39 patients were enrolled in this multicenter Phase II trial performed in the Minnie Pearl Cancer Research Network. Twenty-seven patients (69%) had adenocarcinoma or poorly differentiated adenocarcinoma; 35 patients (90%) had previously received treatment with chemotherapy regimens containing both a platinum agent and a taxane. Only 21% of patients had ever responded to previous therapy. Gemcitabine 1000 mg/m2 was administered intravenously on days 1, 8, and 15 of each 28-day course. Three of 36 evaluable patients (8%) had partial responses, and 9 patients (25%) had minor responses or stable disease with improved symptoms. The median time to progression for patients with partial responses or stable disease/improved symptoms was 5 months. Treatment was well tolerated, with uncommon grade 3 or 4 toxicity. Gemcitabine produced a low objective response rate in this refractory patient population, although approximately one-third of patients experienced symptomatic improvement. Treatment with gemcitabine was well tolerated. Because gemcitabine has activity against a variety of adenocarcinomas, further evaluation of this agent as part of first-line therapy for patients with carcinoma of unknown primary site is appropriate.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::676c0f4fafe3165b1d10116845868c1e https://pubmed.ncbi.nlm.nih.gov/11405172 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.