The case for plant-made veterinary immunotherapeutics
| Autor: | Larry A. Holbrook, Udo Conrad, Bert Devriendt, Jacqueline MacDonald, Rebecca Irwin, Andrew A. Potter, Robert M. Friendship, Tsafrir S. Mor, Martin Lessard, Heribert Warzecha, Jussi Joensuu, Igor Kolotilin, Rima Menassa, Tim A. McAllister, Oksana Yarosh, Anna Depicker, J. Chris Hall, Han Sang Yoo, Ketan Doshi, Eva Stoger, Edward Topp, Eric Cox, Marike Dussault, Vikram Virdi, Michael D. McLean |
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| Rok vydání: | 2016 |
| Předmět: |
Veterinary Medicine
0106 biological sciences 0301 basic medicine Livestock antibiotic resistance Capital investment Food animal Molecular Farming ta220 immunotherapeutic Bioengineering molecular farming plant biotechnology Biology 01 natural sciences Applied Microbiology and Biotechnology Animal Diseases 03 medical and health sciences Antibiotic resistance SDG 3 - Good Health and Well-being antibody Animals ta219 ta318 livestock production business.industry ta1182 Plants Disease control Recombinant Proteins Biotechnology Product (business) veterinary vaccine Oral immunization 030104 developmental biology Immunotherapy business recombinant protein 010606 plant biology & botany |
| Zdroj: | Topp, E, Irwin, R, McAllister, T, Lessard, M, Joensuu, J J, Kolotilin, I, Conrad, U, Stöger, E, Mor, T, Warzecha, H, Hall, C J, McLean, M D, Cox, E, Devriendt, B, Potter, A, Depicker, A, Virdi, V, Holbrook, L, Doshi, K, Dussault, M, Friendship, R, Yarosh, O, Yoo, H S, MacDonald, J & Menassa, R 2016, ' The case for plant-made veterinary immunotherapeutics ', Biotechnology Advances, vol. 34, no. 5, pp. 597-604 . https://doi.org/10.1016/j.biotechadv.2016.02.007 |
| ISSN: | 0734-9750 |
| DOI: | 10.1016/j.biotechadv.2016.02.007 |
| Popis: | The excessive use of antibiotics in food animal production has contributed to resistance in pathogenic bacteria, thereby triggering regulations and consumer demands to limit their use. Alternatives for disease control are therefore required that are cost-effective and compatible with intensive production. While vaccines are widely used and effective, they are available against a minority of animal diseases, and development of novel vaccines and other immunotherapeutics is therefore needed. Production of such proteins recombinantly in plants can provide products that are effective and safe, can be orally administered with minimal processing, and are easily scalable with a relatively low capital investment. The present report thus advocates the use of plants for producing vaccines and antibodies to protect farm animals from diseases that have thus far been managed with antibiotics; and highlights recent advances in product efficacy, competitiveness, and regulatory approval. |
| Databáze: | OpenAIRE |
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