| Autor: |
Bonilla-Lara David, Gamez-Nava Jorge Ivan, Perez-Guerrero Edsaul Emilio, Murillo-Saich Jessica Daniela, Contreras-Haro Betsabe, Vazquez-Villegas Maria Luisa, Fajardo-Robledo Nicte Selene, Aguilar-Chavez Erika Anita Guadalupe, Saldaña-Cruz Ana Miriam, Celis Alfredo, Nava-Valdivia Cesar Arturo, Hernandez-Corona Diana Mercedes, Cardona-Muñoz Ernesto German, Laura Gonzalez-Lopez |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
PloS one. 17(10) |
| ISSN: |
1932-6203 |
| Popis: |
Background Only two previous studies in systemic lupus erythematosus (SLE) patients have identified that the blood concentrations of uromodulin are lower in nephritis. However, none of them had evaluated whether a low serum uromodulin adjusted by the glomerular filtration rate (sUromod/eGFR index) contributed to identify patients in risk of lupus nephritis (LN) using multivariable models. Aim Therefore, this study aimed two objectives to evaluate the association between low serum uromodulin levels and low sUromod adjusted by eGFR with renal flares in SLE excluding effects of potential confounders in multivariable analyses; and to identify the value of low sUmod and low sUmod/eGFR index as a potential diagnostic marker of LN. Patients and methods Design: Cross-sectional study. SLE patients (n = 114) were investigated for lupus flare with renal SLEDAI. Two groups: a) SLE with renal flare (renal-SLEDAI≥4, n = 41) and b) SLE non-renal flare (renal SLEDAI Results Low serum uromodulin and low sUromod/eGFR index correlated to high scores of renal-SLEDAI, SLICC-renal and proteinuria. SLE patients with a renal flare had lower uromodulin levels compared to SLE patients without renal flare (p = 0.004). After adjusting by potential confounders, the low sUromod/eGFR index ( Conclusions We propose the low sUromod/eGFR index as a potential new marker of renal disease activity in SLE. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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