Can Cranberry Juice Protect against Rotenone-Induced Toxicity in Rats?
| Autor: | Ewa Ignatowicz, Małgorzata Kujawska, Jadwiga Jodynis-Liebert, Judyta Cielecka-Piontek, Małgorzata Ewertowska, Przemysław Zalewski, Monika Kurpik |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Male Antioxidant medicine.medical_treatment Pharmacology medicine.disease_cause Antioxidants Lipid peroxidation chemistry.chemical_compound 0302 clinical medicine oxidative stress food.beverage Kidney Brain Diseases Nutrition and Dietetics liver kidney brain serum polyphenols HPLC analysis Liver Diseases CRANBERRY JUICE food and beverages Fruit and Vegetable Juices medicine.anatomical_structure Vaccinium macrocarpon Toxicity Kidney Diseases lcsh:Nutrition. Foods and food supply DNA damage lcsh:TX341-641 macromolecular substances complex mixtures Article 03 medical and health sciences food Rotenone medicine Animals Rats Wistar Uncoupling Agents technology industry and agriculture Rats Disease Models Animal 030104 developmental biology chemistry 030217 neurology & neurosurgery Oxidative stress Food Science DNA Damage |
| Zdroj: | Nutrients, Vol 13, Iss 1050, p 1050 (2021) Nutrients Nutrients; Volume 13; Issue 4; Pages: 1050 |
| ISSN: | 2072-6643 |
| Popis: | The high polyphenols content of cranberry accounts for its strong antioxidant activity underlying the beneficial health effects of this fruit. Rotenone (ROT) is a specific inhibitor of mitochondrial complex I in the brain which leads to the generation of oxidative stress. To date, there are few data indicating that toxicity of ROT is not limited to the brain but can also affect other tissues. We aimed to examine whether ROT-induced oxidative stress could be counteracted by cranberry juice not only in the brain but also in the liver and kidney. Wistar rats were given the combined treatment with ROT and cranberry juice (CJ) for 35 days. Parameters of antioxidant status were determined in the organs. ROT enhanced lipid peroxidation solely in the brain. The increase in the DNA damage was noticed in all organs examined and in leukocytes. The beneficial effect of CJ on these parameters appeared only in the brain. Additionally, CJ decreased the activity of serum hepatic enzymes. The effect of CJ on antioxidant enzymes was not consistent, however, in some organs, CJ reversed changes evoked by ROT. Summing up, ROT can cause oxidative damage not only in the brain but also in other organs. CJ demonstrated a protective effect against ROT-induced toxicity. |
| Databáze: | OpenAIRE |
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