Th1/Th2 polarization by viral and helminth infection in birds
| Autor: | Virgil E.J.C. Schijns, Peter K. Kaiser, Winfried G J Degen, Nancy van Daal, Lisa Rothwell |
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| Jazyk: | angličtina |
| Rok vydání: | 2005 |
| Předmět: |
Avian immune system
Newcastle Disease animal diseases Newcastle disease virus Biology Ascaridia Microbiology ChIL-13 Th2 Cells Immune system Ileum Immunity Extracellular Animals Helminths RNA Messenger Th1/Th2 polarization Ascaridiasis Poultry Diseases ChIFN-y Immunity Cellular Base Sequence General Veterinary Reverse Transcriptase Polymerase Chain Reaction Mammalian Semi-quantitative RT-PCR General Medicine T lymphocyte Th1 Cells biochemical phenomena metabolism and nutrition Biological Evolution Virology Chicken Specific Pathogen-Free Organisms Cytokines Viral disease Chickens Spleen Intracellular |
| Zdroj: | Degen, W G J, Daal, N V, Rothwell, L, Kaiser, P & Schijns, V E J C 2005, ' Th1/Th2 polarization by viral and helminth infection in birds ', Veterinary Microbiology, vol. 105, no. 3-4, pp. 163-7 . https://doi.org/10.1016/j.vetmic.2004.12.001 |
| DOI: | 10.1016/j.vetmic.2004.12.001 |
| Popis: | Mammals developed an immune system able to functionally polarize into so-called type 1 or type 2 immune pathways, to resolve infections with intracellular and extracellular pathogens, respectively. In the well-studied avian immune system of the chicken, however, no evidence for polarized immunity could be found, as yet. To investigate whether these two major arms of mammalian immunity, regulated by a T helper (Th)1/Th2 cytokine balance, evolved similarly in birds, chickens were exposed to a prevalent intracellular (viral) or extracellular (helminth) infection. By using semi-quantitative RT-PCR analysis we provide evidence that polarization of Th1/Th2 type immunity extends beyond mammalian species, and, therefore, has been evolutionary conserved for more than 300 million years, when the lineages of mammalian and avian vertebrates are assumed to have segregated. |
| Databáze: | OpenAIRE |
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