Intake levels of dietary long-chain PUFAs modify the association between genetic variation in FADS and LDL-C[S]
| Autor: | Elisabet Wirfält, Bo Hedblad, Sophie Hellstrand, Bo Gullberg, Emily Sonestedt, Marju Orho-Melander, Ulrika Ericson |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Fatty Acid Desaturases
Male medicine.medical_specialty Linoleic acid Blood lipids QD415-436 Endocrinology and Diabetes Polymorphism Single Nucleotide Biochemistry low density lipoprotein cholesterol chemistry.chemical_compound Endocrinology Diet and cancer Dietary Fats Unsaturated Internal medicine medicine Humans Cardiac and Cardiovascular Systems Alleles Triglycerides chemistry.chemical_classification Nutrition and Dietetics Triglyceride biology fatty acid desaturase business.industry Cholesterol Cholesterol HDL cholesterol Cholesterol LDL Cell Biology cohort Middle Aged Fatty acid desaturase chemistry Genetic Loci Fatty Acids Unsaturated biology.protein Female lipids (amino acids peptides and proteins) epidemiology Patient-Oriented and Epidemiological Research business diet Lipoprotein Polyunsaturated fatty acid polyunsaturated fatty acids |
| Zdroj: | Journal of Lipid Research, Vol 53, Iss 6, Pp 1183-1189 (2012) Journal of Lipid Research Journal of Lipid Research; 53(6), pp 1183-1189 (2012) |
| ISSN: | 0022-2275 1183-1189 1539-7262 |
| Popis: | Polymorphisms of the FA desaturase (FADS) gene cluster have been associated with LDL, HDL, and triglyceride concentrations. Because FADS converts alpha-linolenic acid (ALA) and linoleic acid into PUFAs, we investigated the interaction between different PUFA intakes and the FADS polymorphism rs174547 (T>C) on fasting blood lipid and lipoprotein concentrations. We included 4,635 individuals (60% females, 45-68 years) from the Swedish population-based Malmo Diet and Cancer cohort. Dietary intakes were assessed by a modified diet history method including 7-day registration of cooked meals. The C-allele of rs174547 was associated with lower LDL concentration (P = 0.03). We observed significant interaction between rs174547 and long-chain omega-3 PUFA intakes on LDL (P = 0.01); the C-allele was only associated with lower LDL among individuals in the lowest tertile of long-chain omega-3 PUFA intakes (P < 0.001). In addition, significant interaction was observed between rs174547 and the ratio of ALA and linoleic FA intakes on HDL (P = 0.03). However, no significant associations between the C-allele and HDL were detected within the intake tertiles of the ratio. Our findings suggest that dietary intake levels of different PUFAs modify the associated effect of genetic variation in FADS on LDL and HDL.-Hellstrand, S., E. Sonestedt, U. Ericson, B. Gullberg, E. Wirfalt, B. Hedblad, and M. Orho-Melander. Intake levels of dietary PUFAs modify the association between genetic variation in FADS and LDL-C. J. Lipid Res. 2012. 53: 1183-1189. |
| Databáze: | OpenAIRE |
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