Ceruletide analgesia in biliary colic
| Autor: | F Celotti, A Pardo, C De Paolis |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Adult
Male Colic Biliary Tract Diseases medicine.medical_treatment Pain Right hypochondrium Biliary colic digestive system law.invention Random Allocation Double-Blind Method law Sphincter of Oddi Humans Medicine Pharmacology (medical) Saline Ceruletide Aged Cholecystokinin Pharmacology Analgesics Clinical pharmacology Referred pain business.industry Middle Aged Anesthesia Injections Intravenous Drug Evaluation Female medicine.symptom business |
| Zdroj: | Clinical Pharmacology and Therapeutics. 36:510-514 |
| ISSN: | 1532-6535 0009-9236 |
| DOI: | 10.1038/clpt.1984.211 |
| Popis: | Ceruletide is a decapeptide isolated from the skin of an Australian frog. Its chemical and biologic relationship to cholecystokinin and its potent relaxant effect on the sphincter of Oddi makes it useful in biliary colic. In this double-blind placebo-controlled experiment, 60 subjects with moderate to severe pain caused by biliary colic were injected with ceruletide, 1 ng/kg iv or with an equal volume of saline solution. Pain in the right hypochondrium, referred pain, and Murphy's sign were scored before and after treatment. Data indicate that ceruletide is effective in biliary colic. Clinical Pharmacology and Therapeutics (1984) 36, 510–514; doi:10.1038/clpt.1984.211 |
| Databáze: | OpenAIRE |
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