Vitamin D and clinical symptoms in First Episode Psychosis (FEP): A prospective cohort study
| Autor: | Robin M. Murray, Oliver D. Howes, Nidhita Singh, Fiona Gaughran, Poonam Gardner-Sood, John Lally, Brendon Stubbs, Marta Di Forti, Dominic Stringer, Anthony S. David, Shubulade Smith, Olesya Ajnakina |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Psychosis Cognitive Cross-sectional study Young Adult 03 medical and health sciences 0302 clinical medicine Internal medicine First episode psychosis medicine Vitamin D and neurology Humans Longitudinal Studies Prospective Studies 25-hydroxyvitamin D (25(OH)D) Vitamin D Young adult Prospective cohort study Biological Psychiatry Negative symptom business.industry FEP medicine.disease 030227 psychiatry Psychiatry and Mental health Cross-Sectional Studies Psychotic Disorders Schizophrenia Longitudinal Female Negative symptoms business 030217 neurology & neurosurgery |
| Zdroj: | Lally, J, Ajnakina, O, Singh, N, Gardner-Sood, P, Stubbs, B, Stringer, D, Di Forti, M, David, A S, Smith, S, Murray, R M, Howes, O D & Gaughran, F 2019, ' Vitamin D and clinical symptoms in First Episode Psychosis (FEP) : a prospective cohort study ', Schizophrenia Research, vol. 204, pp. 381-388 . https://doi.org/10.1016/j.schres.2018.08.011 |
| ISSN: | 0920-9964 |
| Popis: | BACKGROUND: There is a paucity of longitudinal research investigating vitamin D in people with early psychosis.METHOD: Vitamin D levels were measured in 168 patients (64% (n = 108) male, mean age 29.3 (9.8) years) with first episode psychosis (FEP), along with measures of clinical state at baseline and at 12 months follow up. We assessed the a) cross sectional, and; b) longitudinal relationships between continuous and categorical 25-hydroxyvitamin D (25(OH)D) levels and clinical symptoms at first contact for psychosis and at 12 months.RESULTS: In FEP, 80% (n = 134) at baseline, and 76% at 12 months follow up, had suboptimal vitamin D levels (CONCLUSION: We identified a prospective association between higher baseline serum Vitamin D levels and lower total psychotic symptoms and negative symptoms of psychosis at 12 months after first contact for psychosis. The results of this study require replication in larger prospective studies, and highlight the need for large randomised trials to assess the effect of vitamin D supplementation on symptoms of psychosis in FEP. |
| Databáze: | OpenAIRE |
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