Direct Detection of Candida albicans with a Membrane Based Electrochemical Impedance Spectroscopy Sensor
| Autor: | Winnie Edith Svendsen, Catarina Almeida, Maria Dimaki, Ida Schjødt, Dorota Kwasny, Sheida Esmail Tehrani |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Pathogen detection
02 engineering and technology lcsh:Chemical technology 01 natural sciences Biochemistry Analytical Chemistry Microbiology lcsh:TP1-1185 Electrical and Electronic Engineering Candida albicans Instrumentation Candida biology Chemistry 010401 analytical chemistry High mortality Impedance sensor Gold standard (test) 021001 nanoscience & nanotechnology biology.organism_classification Atomic and Molecular Physics and Optics Yeast 0104 chemical sciences Dielectric spectroscopy membrane based sensor Membrane electrochemical impedance spectroscopy Membrane based sensor 0210 nano-technology Electrochemical impedance spectroscopy |
| Zdroj: | Sensors, Vol 18, Iss 7, p 2214 (2018) Kwasny, D, Esmail Tehrani, S, Almeida, C, Schjødt, I, Dimaki, M & Svendsen, W E 2018, ' Direct detection of candida albicans with a membrane based electrochemical impedance spectroscopy sensor ', Sensors, vol. 18, no. 7, 2214 . https://doi.org/10.3390/s18072214 Sensors Volume 18 Issue 7 |
| ISSN: | 1424-8220 |
| Popis: | Candidemia and invasive candidiasis is a cause of high mortality and morbidity rates among hospitalized patients worldwide. The occurrence of the infections increases due to the complexity of the patients and overuse of the antifungal therapy. The current Candida detection method includes blood culturing which is a lengthy procedure and thus delays the administration of the antifungal therapy. Even though the results are available after 48 h it is still the gold standard in pathogen detection in a hospital setting. In this work we present an electrochemical impedance sensor that is capable of detecting Candida albicans yeast. The yeast cells are captured on electrodes specifically functionalized with anti-Candida antibodies and detection is achieved by electrochemical impedance spectroscopy. The sensor allows for detection of the yeast cells at clinically relevant concentrations in less than 1 h. |
| Databáze: | OpenAIRE |
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