Genomic Analysis of Salmonella enterica Serovar Typhimurium DT160 Associated with a 14-Year Outbreak, New Zealand, 1998–2012

Autor: Anne C. Midwinter, Nigel P. French, David T. S. Hayman, Alison E. Mather, Patrick J. Biggs, Samuel J. Bloomfield, Jonathan C. Marshall, Philip E. Carter, Jackie Benschop
Přispěvatelé: Apollo - University of Cambridge Repository
Rok vydání: 2017
Předmět:
Salmonella typhimurium
0301 basic medicine
Serotype
Salmonella
Time Factors
Epidemiology
lcsh:Medicine
medicine.disease_cause
Disease Outbreaks
0302 clinical medicine
origin
030212 general & internal medicine
Genomic Analysis of Salmonella enterica Serovar Typhimurium DT160 Associated with a 14-Year Outbreak
New Zealand
1998–2012
bacteria
Pathogen
Bird Diseases
biology
Transmission (medicine)
poultry
transmission
Salmonella enterica
Infectious Diseases
Salmonella Infections
definitive type 160
gastroenteritis
Microbial genetics
Microbiology (medical)
Zoology
Animals
Wild
lcsh:Infectious and parasitic diseases
Birds
03 medical and health sciences
genomics
medicine
Animals
Humans
Microbiology not elsewhere classified
lcsh:RC109-216
wild birds
Salmonella Infections
Animal
outbreak
molecular evolution
Host (biology)
Research
enteric infections
multi-host pathogen
lcsh:R
Outbreak
Bacteriology
biology.organism_classification
Virology
030104 developmental biology
serovar Typhimurium DT160
bovids
New Zealand
Zdroj: Emerging Infectious Diseases, Vol 23, Iss 6, Pp 906-913 (2017)
Emerging Infectious Diseases
ISSN: 1080-6059
1080-6040
DOI: 10.3201/eid2306.161934
Popis: During 1998-2012, an extended outbreak of Salmonella enterica serovar Typhimurium definitive type 160 (DT160) affected > 3,000 humans and killed wild birds in New Zealand. However, the relationship between DT160 within these 2 host groups and the origin of the outbreak are unknown. Whole-genome sequencing was used to compare 109 Salmonella Typhimurium DT160 isolates from sources throughout New Zealand. We provide evidence that DT160 was introduced into New Zealand around 1997 and rapidly propagated throughout the country, becoming more genetically diverse over time. The genetic heterogeneity was evenly distributed across multiple predicted functional protein groups, and we found no evidence of host group differentiation between isolates collected from human, poultry, bovid, and wild bird sources, indicating ongoing transmission between these host groups. Our findings demonstrate how a comparative genomic approach can be used to gain insight into outbreaks, disease transmission, and the evolution of a multihost pathogen after a probable point-source introduction.
Databáze: OpenAIRE
Externí odkaz: