Editor's Highlight: Periodic Exposure to Smartphone-Mimic Low-Luminance Blue Light Induces Retina Damage Through Bcl-2/BAX-Dependent Apoptosis
| Autor: | Hui Wen Cheng, Fan Li Lin, Shih Hsuan Huang, Cheng Hui Lin, Ching Hao Li, George Hsiao, Yu Wen Cheng, Jau Der Ho, Chi Hao Tsai, Man Ru Wu, Jaw Jou Kang |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Retinal degeneration Light Apoptosis Caspase 3 Toxicology Retina Fas ligand 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine Animals FADD Cells Cultured bcl-2-Associated X Protein Retinal pigment epithelium biology Chemistry Retinal medicine.disease Rats Cell biology 030104 developmental biology medicine.anatomical_structure 030221 ophthalmology & optometry biology.protein Smartphone Protein Binding |
| Zdroj: | Toxicological Sciences. 157:196-210 |
| ISSN: | 1096-0929 1096-6080 |
| Popis: | Blue light-induced phototoxicity plays an important role in retinal degeneration and might cause damage as a consequence of smartphone dependency. Here, we investigated the effects of periodic exposure to blue light-emitting diode in a cell model and a rat retinal damage model. Retinal pigment epithelium (RPE) cells were subjected to blue light in vitro and the effects of blue light on activation of key apoptotic pathways were examined by measuring the levels of Bcl-2, Bax, Fas ligand (FasL), Fas-associated protein with death domain (FADD), and caspase-3 protein. Blue light treatment of RPE cells increased Bax, cleaved caspase-3, FasL, and FADD expression, inhibited Bcl-2 and Bcl-xL accumulation, and inhibited Bcl-2/Bax association. A rat model of retinal damage was developed with or without continuous or periodic exposure to blue light for 28 days. In this rat model of retinal damage, periodic blue light exposure caused fundus damage, decreased total retinal thickness, caused atrophy of photoreceptors, and injured neuron transduction in the retina. |
| Databáze: | OpenAIRE |
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