Synthesis, stereochemical assignment and biological activity of a novel series of C-4″ modified aza-Macrolides

Autor:	Margaret A. Rushing, Sheryl L. Santoro, Barbara J. Kamicker, Bingwei V Yang, Michael A. Letavic, Camilla D. Bertsche, Bronk Brian Scott, Laura J. L. Norcia, Shigeru F. Hayashi, Nicole L. Kolosko, David M. George
Rok vydání:	2003
Předmět:	Pasteurella multocida Stereochemistry Pasteurella Infections Clinical Biochemistry Molecular Conformation Pharmaceutical Science Stereoisomerism Microbial Sensitivity Tests Biochemistry Chemical synthesis Mice Structure-Activity Relationship chemistry.chemical_compound Drug Discovery Escherichia coli Animals Structure–activity relationship Molecular Biology Hexoses Antibacterial agent Cladinose chemistry.chemical_classification Aza Compounds Organic Chemistry Biological activity Anti-Bacterial Agents Disease Models Animal chemistry Aldose Molecular Medicine Macrolides Lactone
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 13:1955-1958
ISSN:	0960-894X
DOI:	10.1016/s0960-894x(03)00358-5
Popis:	Modification of the cladinose C-4" position via manipulation of the corresponding keto derivatives afforded two stereochemically pure series of compounds. The synthesis and structure determination of these compounds is described within. The in vitro and in vivo biological activity of this novel series of C-4" modified macrolides is also described.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::675fc379e9f64d30889ce782c5089ea5 https://doi.org/10.1016/s0960-894x(03)00358-5 Zobrazit plný text záznamu Full Text from ScienceDirect