Stachylines A-D from the sponge-derived fungus Stachylidium sp
| Autor: | Gabriele M. König, Natalja Part, Stefan Kehraus, Sarah Bouhired, Celso Almeida |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Stereochemistry
Pharmaceutical Science Stereoisomerism Marine Biology Fungus Microbial Sensitivity Tests Article Analytical Chemistry chemistry.chemical_compound Drug Discovery Organic chemistry Animals Nuclear Magnetic Resonance Biomolecular Pharmacology biology Molecular Structure Organic Chemistry Absolute configuration Fungi Oxime biology.organism_classification Terpenoid Porifera Sponge Complementary and alternative medicine chemistry Callyspongia Molecular Medicine Tyrosine Stachylidium Drug Screening Assays Antitumor |
| Zdroj: | Journal of natural products. 74(1) |
| ISSN: | 1520-6025 |
| Popis: | The marine-derived fungus Stachylidium sp. was isolated from the sponge Callyspongia cf. C. flammea. Four new, putatively tyrosine-derived and O-prenylated natural products, stachylines A-D (1-4), were obtained from the fungal extract. The structures of 1-4 were elucidated on the basis of extensive spectroscopic analyses. The absolute configuration of compound 2 was established by Mosher's method. Stachyline A (1) possesses a rare terminal oxime group and occurs as an interchangeable mixture of E/Z-isomers. |
| Databáze: | OpenAIRE |
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