Progestagen-only oral contraceptives: Comparison of the metabolic effects of levonorgestrel and norethisterone
| Autor: | M. J. Ball, E. Ashwell, M. D. G. Gillmer |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Adult
medicine.medical_specialty Norethisterone Adolescent Lipoproteins Blood Pressure Levonorgestrel Fibrinogen Hemoglobins chemistry.chemical_compound Risk Factors Oral administration Internal medicine Humans Medicine Blood Coagulation Factor VII business.industry Factor X Body Weight Antithrombin Obstetrics and Gynecology Glucose Tolerance Test Patient Acceptance of Health Care Lipid Metabolism Blood Coagulation Factors Glucose Blood pressure Endocrinology Reproductive Medicine chemistry Female Norethindrone business medicine.drug |
| Zdroj: | Contraception. 44:223-233 |
| ISSN: | 0010-7824 |
| DOI: | 10.1016/0010-7824(91)90014-7 |
| Popis: | A 6-month single-blind study compared the use of a progestagen-only oral contraceptive containing norethisterone 350 micrograms/day (NE 350) with one containing levonorgestrel 30 micrograms (LN 30), to assess the metabolic effects. At the end of 6 months, there were no significant differences between the two groups with respect to plasma cholesterol, lipoproteins including HDL subfractions, triglycerides or glucose concentration. Levels of fibrinogen, plasminogen, Factor VII, Factor X and antithrombin III were also similar. Women changing from a combined oral contraceptive to LN 30 showed a significant fall in Factor X. Mean blood pressure fell on LN 30 by 7/9 mmHg, but the 6-month reading did not differ significantly from that in women on NE 350. Acceptability, and the metabolic effects of the two preparations were similar in this study. Further larger studies are warranted. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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