A case of acute myelogenous leukemia characterized by arterial and venous thrombosis
| Autor: | Chunying Lin, Mingchuan Ba, Huasheng Liang, Pengcheng He, Chen Li, Haoping Li, Zhiqiang Guo |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Lupus anticoagulant Acute myelogenous leukemia (AML) business.industry medicine.drug_class Warfarin Low molecular weight heparin Case Report 030204 cardiovascular system & hematology medicine.disease Thrombosis Pulmonary embolism 03 medical and health sciences Venous thrombosis 0302 clinical medicine Embolism 030220 oncology & carcinogenesis Internal medicine hemic and lymphatic diseases Cardiology Medicine Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Cardiovasc Diagn Ther |
| Popis: | Acute myelogenous leukemia (AML) is a malignant disease of the hematopoietic system, characterized by features of bone marrow insufficiency and organ infiltration by leukemic cells. Venous thrombosis in AML patients is uncommon, compared to bleeding; therefore in patients with AML, simultaneous occurrence of venous and arterial thrombosis is a rather rare presentation. We reported an unusual case of anti-phospholipid antibody syndrome secondary to AML characterized by venous and arterial thrombosis. A 70-year-old man with deep venous thrombosis (DVT) of the left leg confirmed by Doppler was seen in our clinic. During treatment with a Vitamin K antagonist (3 mg daily of Warfarin) and a low molecular weight heparin (LMWH), he developed an acute pulmonary embolism and an acute inferior wall ST elevation myocardial infarction (STEMI), a result of right coronary artery embolism. His full blood count showed leukocytosis and thrombocytopenia. Lupus anticoagulant and anti-cardiolipin antibodies were positive. A bone marrow aspirate test showed results consistent with AML (FAB class M1). A diagnosis of antiphospholipid antibody syndrome secondary to AML characterized by coronary artery embolism, pulmonary embolism and left leg DVT was eventually established. He received anticoagulation with a low dose of warfarin after refusing chemotherapy. He however died of cerebral hemorrhage despite the fact that the INR was in the normal therapeutic range. It is challenging to anticoagulated AML patients complicated by multiple vascular thromboses and thrombocytopenia. |
| Databáze: | OpenAIRE |
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