Chronic experimental infection by Trypanosoma cruzi in Cebus apella monkeys
| Autor: | N. Bolomo, P. Cossio, M. Moreno, Angel Sinagra, Marta A. Lauricella, Adelina Riarte, Elsa L. Segura, R. Arana |
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| Rok vydání: | 1995 |
| Předmět: |
Male
Microbiology (medical) Pathology medicine.medical_specialty lcsh:Arctic medicine. Tropical medicine Myocarditis lcsh:RC955-962 Trypanosoma cruzi lcsh:QR1-502 Parasitemia Cebus apella lcsh:Microbiology reinfection Serology monkeys Fibrosis parasitic diseases medicine Animals Cebus Chagas Disease Amastigote biology chronic infection biology.organism_classification medicine.disease animal models Disease Models Animal Titer Chronic infection Immunology |
| Zdroj: | Memórias do Instituto Oswaldo Cruz., Vol 90, Iss 6, Pp 733-740 (1995) Memórias do Instituto Oswaldo Cruz, Volume: 90, Issue: 6, Pages: 733-740, Published: DEC 1995 |
| ISSN: | 0074-0276 |
| DOI: | 10.1590/s0074-02761995000600014 |
| Popis: | Twenty young male Cebus apella monkeys were infected with CA1 Trypanosoma cruzi strain and reinfected with CA1 or Tulahuen T. cruzi strains, with different doses and parasite source. Subpatent parasitemia was usually demonstrated in acute and chronic phases. Patent parasitemia was evident in one monkey in the acute phase and in four of them in the chronic phase after re-inoculations with high doses of CA1 strain. Serological conversion was observed in all monkeys; titers were low, regardless of the methods used to investigate anti-T. cruzi specific antibodies. Higher titers were induced only when re-inoculations were performed with the virulent Tulahuén strain or high doses of CA1 strain. Clinical, electrocardiographic and ajmaline test evaluations did not reveal changes between infected and control monkeys. Histopathologically, cardiac lesions were always characterized by focal or multifocal mononuclear infiltrates and/or isolated fibrosis, as seen during the acute and chronic phases; neither amastigote nests nor active inflammation and fibrogenic processes characteristic of human acute and chronic myocarditis respectively, were observed. These morphological aspects more closely resemble those found in the "indeterminate phase" and contrast with the more diffuse and progressive pattern of the human chagasic chronic myocarditis. All monkeys survived and no mortality was observed. |
| Databáze: | OpenAIRE |
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