Herpes Simplex Virus Mistyping due to HSV-1 x HSV-2 Interspecies Recombination in Viral Gene Encoding Glycoprotein B
| Autor: | Christine Johnston, Anna Wald, Meei-Li Huang, Keith R. Jerome, Hong Xie, Alexander L. Greninger, Amanda M. Casto |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
chemistry.chemical_classification
0303 health sciences 030306 microbiology Interspecies Recombination viruses HSL and HSV Biology medicine.disease_cause Virology Viral gene 3. Good health 03 medical and health sciences Herpes simplex virus chemistry medicine Glycoprotein B Glycoprotein Gene Recombination 030304 developmental biology |
| DOI: | 10.1101/2020.02.25.965426 |
| Popis: | Human herpes simplex viruses (HSV) 1 and 2 are most often typed via molecular assays. Here we describe the first known case of HSV mistyping due to a previously undescribed HSV-1 x HSV-2 recombination event in UL27, the gene that encodes glycoprotein B. This is the first reported HSV interspecies recombination event impacting this gene, which is frequently used as a target for diagnostics and experimental therapeutics. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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